ANT3 Activators
ANT3 activators belong to a specialized category of chemical compounds that interact with the Adenine Nucleotide Translocase 3 (ANT3) protein, a key component of the mitochondrial inner membrane. ANT3 is a member of the adenine nucleotide translocase family, which plays a crucial role in the transport of adenine nucleotides, specifically ATP (adenosine triphosphate) and ADP (adenosine diphosphate), across the mitochondrial inner membrane. This transport process is essential for maintaining the balance of energy-rich molecules within mitochondria, which are the primary sites of cellular energy production through oxidative phosphorylation. When activated by specific compounds, ANT3 may undergo conformational changes or interactions that influence its ability to transport adenine nucleotides into and out of the mitochondrial matrix.
The activation of ANT3 is a critical step in regulating mitochondrial energy metabolism and cellular bioenergetics. These activators can modulate the transport kinetics of ATP and ADP, affecting the overall efficiency of ATP production and cellular respiration. As mitochondria are central to energy production and play a crucial role in various cellular processes, understanding the chemical properties and mechanisms underlying ANT3 activation is essential for unraveling the complexities of mitochondrial function. Research in this field can provide insights into the broader landscape of cellular bioenergetics, mitochondrial physiology, and the regulation of energy balance, contributing to a deeper understanding of how cells generate and utilize energy to support their functions.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Sodium (meta)arsenite is a toxic metalloid shown to induce mitochondrial dysfunction and oxidative stress. Studies demonstrate that arsenite treatment increases ANT3 expression at the transcriptional level in mouse models, potentially through activated stress response pathways. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
An anthracycline antibiotic, doxorubicin generates reactive oxygen species and causes DNA damage during chemotherapy. Research links doxorubicin's induction of DNA damage and oxidative stress to elevated ANT3 mRNA and protein levels in cardiac myocytes and cancer cells. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
As a platinum-containing chemotherapeutic that induces apoptosis, cisplatin treatment correlates with ANT3 upregulation in ovarian tumor cell lines. The DNA damage response to cisplatin may mediate this ANT3 transcriptional response. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
By inhibiting ribonucleotide reductase to deplete deoxynucleotide triphosphate pools, hydroxyurea creates DNA replicative stress. Resulting reports show hydroxyurea boosts ANT3 expression in lymphocytes and cancer models, potentially through DNA damage signaling. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $26.00 $36.00 $47.00 $136.00 $455.00 | 3 | |
Vitamin K3 is a vitamins K metabolite inducing oxidative stress through redox cycling. Studies associate menadione's generation of reactive oxygen species with increased levels of protective ANT3 transcript in cardiomyocytes and hepatic cells. | ||||||
tert-Butyl hydroperoxide aqueous solution | 75-91-2 | sc-251134 sc-251134A | 100 ml 500 ml | $46.00 $100.00 | 1 | |
tert-Butyl hydroperoxide triggers oxidative stress within cells. Research links this compound's induction of oxidative damage to enhanced ANT3 protein abundance aimed at antioxidant functions in neuronal-like cells. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Found naturally in fruits and nuts, ellagic acid shows antioxidant properties antioxidant properties. Reports associate ellagic acid with ANT3 induction in cell culture systems, likely through activation of stress-related signaling. | ||||||