ANT3 Antibody (2A9): sc-293434

ANT3 Antibody (2A9) is a mouse monoclonal IgG3 kappa light chain antibody that detects ANT3 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-ANT3 antibody (2A9) is available as the non-conjugated format. ANT3, also known as SLC25A6, ADP/ATP translocase 3, or AAC3, is a crucial 298 amino acid mitochondrial protein that plays a significant role in cellular energy metabolism by facilitating the exchange of ADP and ATP across the mitochondrial inner membrane. This exchange maintains cellular energy balance, as ATP serves as the primary energy currency, while ADP is a key substrate for ATP regeneration. ANT3 is implicated in forming the permeability transition pore complex (PTPC), a structure that regulates apoptosis, highlighting ANT3′s importance in cell survival and death pathways. ANT3 is encoded by a gene located on the pseudoautosomal region 1 (PAR1) of the X and Y chromosomes and features three solcar repeats, which are essential for function. ANT3 interacts with various proteins, including VPRBP (HIV-1 Vpr) and influenza A virus PB1-F2, indicating potential involvement in viral pathogenesis and cellular stress responses.

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ANT3 Antibody (2A9) References:

1. Mitochondrial adenine nucleotide translocator 3 is regulated by IL-4 and IFN-gamma via STAT-dependent pathways.  |  Jang, JY. and Lee, CE. 2003. Cell Immunol. 226: 11-9. PMID: 14746803
2. Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells.  |  Zamora, M., et al. 2004. FEBS Lett. 563: 155-60. PMID: 15063741
3. Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1.  |  Zamarin, D., et al. 2005. PLoS Pathog. 1: e4. PMID: 16201016
4. Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells.  |  Yang, Z., et al. 2007. Mol Biol Cell. 18: 4681-9. PMID: 17855512
5. DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase.  |  Cozens, AL., et al. 1989. J Mol Biol. 206: 261-80. PMID: 2541251
6. Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.  |  Houldsworth, J. and Attardi, G. 1988. Proc Natl Acad Sci U S A. 85: 377-81. PMID: 2829183
7. Discovery and validation of FBLN1 and ANT3 as potential biomarkers for early detection of cervical cancer.  |  Hao, Y., et al. 2021. Cancer Cell Int. 21: 125. PMID: 33602229
8. MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.  |  Ji, X., et al. 2023. iScience. 26: 106656. PMID: 37182101
9. EFHD1 promotes osteosarcoma proliferation and drug resistance by inhibiting the opening of the mitochondrial membrane permeability transition pore (mPTP) by binding to ANT3.  |  Shen, X., et al. 2024. Cell Mol Life Sci. 81: 236. PMID: 38795203
10. ANT3 and STS are autosomal in prosimian lemurs: implications for the evolution of the pseudoautosomal region.  |  Toder, R., et al. 1995. Hum Genet. 95: 22-8. PMID: 7814020
11. A human pseudoautosomal gene encodes the ANT3 ADP/ATP translocase and escapes X-inactivation.  |  Slim, R., et al. 1993. Genomics. 16: 26-33. PMID: 8486369
12. A human pseudoautosomal gene, ADP/ATP translocase, escapes X-inactivation whereas a homologue on Xq is subject to X-inactivation.  |  Schiebel, K., et al. 1993. Nat Genet. 3: 82-7. PMID: 8490661