Annexin IV Inhibitors

Annexin IV Inhibitors include a variety of compounds that can suppress or modulate the activity of Annexin IV. This class notably comprises calcium chelators like EGTA and BAPTA, which reduce the availability of calcium ions, crucial for Annexin IV's function. The presence of these chelators might inhibit the calcium-dependent binding of Annexin IV to phospholipids.

Additionally, this class incorporates phospholipase inhibitors and compounds like Neomycin, Rifampicin, Propranolol, Lidocaine, and Tetracaine, which can interact with or alter the composition of phospholipids, affecting Annexin IV's binding ability. Calcium channel blockers such as Verapamil, Nifedipine, and Diltiazem are included due to their capacity to reduce intracellular calcium levels, thereby inhibiting Annexin IV's calcium-dependent activity. Amiloride, known for its effects on ion channels, is also considered due to its impact on cellular calcium homeostasis.