Angptl5 Activators

Chemicals categorized as Angptl5 activators potentially act through various signaling pathways to modulate the expression or activity of Angptl5 indirectly. The peroxisome proliferator-activated receptor (PPAR) agonists, such as rosiglitazone and pioglitazone, activate nuclear receptors that play a significant role in lipid metabolism and adipogenesis and can also influence the expression of proteins involved in angiogenesis. Fenofibrate and bezafibrate, as PPARα and pan-agonists, respectively, potentially influence lipid metabolism pathways, which could subsequently affect Angptl5, given the protein's association with lipid metabolism and angiogenesis.

Compounds like LY294002 and rapamycin target key kinases in the PI3K/Akt/mTOR pathway, which is crucial for cell growth, proliferation, and survival, as well as angiogenesis, a biological process in which Angptl5 is potentially involved. Modulation of this pathway can lead to altered expression of angiogenic factors. Similarly, activation of AMPK by AICAR or its precursor can influence energy homeostasis and metabolic signaling pathways, which could lead to changes in Angptl5 activity. Nicotinamide, a precursor of NAD+, and resveratrol, an activator of SIRT1, can influence metabolic and stress response pathways, which might indirectly affect Angptl5 expression or activity. Quercetin and epigallocatechin gallate (EGCG) have been shown to modulate various cellular signaling pathways, including those related to angiogenesis and metabolism, and thus may also impact Angptl5 expression indirectly.