Amylin Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in intracellular cAMP levels. Elevated cAMP levels can indirectly inhibit Amylin secretion from pancreatic beta cells by interfering with calcium influx and downstream signaling pathways. | ||||||
Exendin-4 | 141758-74-9 | sc-474611 sc-474611A | 500 µg 1 mg | $146.00 $198.00 | 1 | |
Exendin-4, a GLP-1 receptor agonist, stimulates insulin secretion and inhibits glucagon release. This indirectly suppresses Amylin production by reducing glucose levels and counteracting the need for additional hormones like Amylin in glucose regulation. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil blocks L-type calcium channels in pancreatic beta cells. This inhibition of calcium influx reduces the release of Amylin, as calcium is a critical signal for its exocytosis, thereby indirectly inhibiting Amylin secretion. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is an antioxidant that can modulate oxidative stress. Elevated oxidative stress is associated with increased Amylin aggregation and toxicity. Quercetin's antioxidant properties can indirectly inhibit Amylin aggregation and related cellular damage. | ||||||
Acarbose | 56180-94-0 | sc-203492 sc-203492A | 1 g 5 g | $226.00 $605.00 | 1 | |
Acarbose is an alpha-glucosidase inhibitor that delays carbohydrate digestion in the gut. By reducing post-meal glucose spikes, acarbose indirectly decreases the demand for Amylin to regulate blood sugar levels, leading to reduced Amylin secretion. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin activates AMP-activated protein kinase (AMPK), which reduces hepatic glucose production and enhances glucose uptake. Lower blood glucose levels achieved with metformin can indirectly inhibit Amylin release by reducing the stimulus for its secretion. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is a calcium channel blocker that primarily targets L-type calcium channels. By blocking calcium entry into pancreatic beta cells, it indirectly reduces Amylin secretion by interrupting the calcium-dependent pathways involved in hormone release. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, found in turmeric, exhibits anti-inflammatory properties and can modulate oxidative stress. These effects indirectly inhibit Amylin aggregation and cytotoxicity, as inflammation and oxidative stress are linked to Amylin-induced cellular damage. | ||||||