α-protein kinase 3 Activators
The classification of α-protein kinase 3 activators encompasses a variety of chemical compounds, primarily those that elevate intracellular cAMP levels, thus promoting the activation of PKA, of which α-protein kinase 3 is a catalytic subunit. Forskolin directly stimulates adenylyl cyclase, leading to an increase in cAMP synthesis. The cAMP analogs like Sp-5,6-DCl-cBIMPS, 8-Br-cAMP, and 6-Bnz-cAMP mimic the action of cAMP, activating PKA directly. PDE inhibitors like rolipram, cilostamide, milrinone, zardaverine, vinpocetine, and anagrelide prevent the degradation of cAMP, thus enhancing the signaling cascade that leads to PKA activation. EPAC activators, such as 8-pCPT-2'-O-Me-cAMP, while not directly activating PKA, affect downstream targets of the cAMP pathway and can modulate kinase activity through these effects.
These chemicals contribute to the modulation of α-protein kinase 3 activity by promoting a cellular environment that favors the phosphorylation state, which is conducive to kinase activation. Such an environment is characterized by increased levels of cAMP, leading to the activation of PKA, and in turn, the phosphorylation of downstream targets, including α-protein kinase 3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Direct activator of adenylyl cyclase, increasing intracellular cAMP levels, which can activate PKA and may lead to subsequent activation of α-protein kinase 3. | ||||||
YC-1 | 170632-47-0 | sc-202856 sc-202856A sc-202856B sc-202856C | 1 mg 5 mg 10 mg 50 mg | $32.00 $122.00 $214.00 $928.00 | 9 | |
A potent and selective cAMP analog that activates PKA, potentially leading to the activation of downstream kinases including α-protein kinase 3. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
A membrane-permeable cAMP analog that activates PKA, which could then phosphorylate and activate α-protein kinase 3. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Selective inhibitor of phosphodiesterase 4 (PDE4), increasing cAMP levels and thereby potentially activating PKA and α-protein kinase 3. | ||||||
8-pCPT-2′-O-Me-cAMP | 634207-53-7 | sc-257020 | 1 mg | $300.00 | 5 | |
Selective activator for the exchange protein directly activated by cAMP (EPAC), which is a downstream effector of cAMP and can influence various signaling pathways, possibly impacting α-protein kinase 3 activity. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $90.00 $350.00 | 16 | |
A selective inhibitor of PDE3, which increases cAMP levels and can thereby activate PKA, potentially impacting α-protein kinase 3 activity. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $162.00 $683.00 | 7 | |
PDE3 inhibitor that leads to increased cAMP levels, enhancing PKA activity which could indirectly activate α-protein kinase 3. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
A flavonoid that has been shown to increase cAMP levels in certain cellular contexts, which could activate PKA and subsequently α-protein kinase 3. | ||||||
Zardaverine | 101975-10-4 | sc-201208 sc-201208A | 5 mg 25 mg | $88.00 $379.00 | 1 | |
A dual PDE3 and PDE4 inhibitor that can raise intracellular cAMP levels, potentially increasing PKA activity and influencing α-protein kinase 3. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
A PDE1 inhibitor that can lead to increased cAMP levels and potentially heightened PKA activity, which might activate α-protein kinase 3. | ||||||