α N-catenin Activators
α N-catenin activators are a class of chemicals that target the modulation of the protein α N-catenin, also known as neuronal cadherin (CDH2), which plays a pivotal role in the establishment and maintenance of synaptic contacts in the nervous system. α N-catenin is involved in cell-cell adhesion processes, linking cadherins to the actin cytoskeleton and thereby influencing cell signaling, synaptic plasticity, and neuronal function.
The activation of α N-catenin by these chemicals may occur through direct or indirect mechanisms. Direct activators might interact with the α N-catenin protein itself, enhancing its affinity for binding partners like cadherins or actin, or facilitating its role in signal transduction pathways that govern synaptic function. This could involve stabilizing the protein structure, preventing its degradation, or promoting its proper localization within the cell, particularly at the synapse. Indirect α N-catenin activators may operate by influencing the expression levels of the protein, either by upregulating the transcription of the CDH2 gene or by stabilizing its mRNA, leading to increased synthesis of α N-catenin. They could also modulate the signaling pathways that impact the function of α N-catenin, such as those involved in the regulation of the cytoskeleton or intercellular junction formation. Furthermore, these activators might affect the phosphorylation status of α N-catenin, which can control its activity and interactions with other proteins. Research involving α N-catenin activators is particularly relevant in the field of neurobiology, where elucidating the molecular underpinnings of synaptic connectivity and plasticity is essential. Understanding how α N-catenin activators work offers insights into the mechanisms that control neuronal circuit formation and adaptation, which is fundamental to the comprehension of learning, memory, and the overall plasticity of the nervous system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine can initiate the translocation of α N-catenin from the cytoplasm to the cell membrane, promoting adhesion and strengthening cell-cell junctions. This is achieved by the activation of H1 receptors, which triggers a signaling cascade involving phospholipase C and protein kinase C, ultimately leading to the activation of α N-catenin. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which phosphorylates α N-catenin, thus increasing its binding affinity for β-catenin, enhancing the stability of the cadherin-catenin complex at the cell membrane and facilitating stronger cell adhesion. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine can stimulate the β2-adrenergic receptor, leading to an increase in cAMP levels. This, in turn, activates protein kinase A (PKA) and subsequent phosphorylation of α N-catenin, enhancing the stability of the cadherin-catenin complex and cell adhesion. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, leading to the activation of PKA. PKA phosphorylates α N-catenin, enhancing the stability of the cadherin-catenin complex and promoting cell adhesion. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $300.00 | ||
Calmodulin binds to and activates calcineurin, a calcium-dependent serine/threonine phosphatase. Calcineurin dephosphorylates α N-catenin, enhancing its interaction with actin and strengthening cell-cell adhesion. | ||||||
Fasudil, Monohydrochloride Salt | 105628-07-7 | sc-203418 sc-203418A sc-203418B sc-203418C sc-203418D sc-203418E sc-203418F | 10 mg 50 mg 250 mg 1 g 2 g 5 g 10 g | $18.00 $33.00 $87.00 $168.00 $253.00 $496.00 $910.00 | 5 | |
Fasudil inhibits Rho-associated protein kinase (ROCK), which phosphorylates and inactivates α N-catenin. By inhibiting ROCK, Fasudil indirectly enhances the activity of α N-catenin, promoting cell adhesion. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine inhibits PDE1, leading to an increase in cAMP and cGMP levels. Increased cAMP activates PKA, which phosphorylates α N-catenin, enhancing the stability of the cadherin-catenin complex and cell-cell adhesion. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits PDE4, leading to an increase in cAMP levels. Increased cAMP activates PKA, which phosphorylates α N-catenin, enhancing the stability of the cadherin-catenin complex and cell-cell adhesion. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 inhibits ROCK, which phosphorylates and inactivates α N-catenin. By inhibiting ROCK, Y-27632 indirectly enhances the activity of α N-catenin, promoting cell adhesion. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $165.00 $697.00 | 7 | |
Milrinone inhibits PDE3, leading to increased cAMP levels. Increased cAMP activates PKA, which phosphorylates α N-catenin, enhancing the stability of the cadherin-catenin complex and cell-cell adhesion. | ||||||