α2-Macroglobulin Activators
α2-Macroglobulin Activators consist of a range of chemical compounds that underpin the enhancement of α2-Macroglobulin's activity through different biochemical mechanisms. Epigallocatechin gallate (EGCG) and curcumin bolster α2-Macroglobulin by tempering the NF-κB pathway, which results in an indirect upsurge in its anti-inflammatory action. Resveratrol augments the protein's activity by enlisting SIRT1, leading to increased antioxidant defense, while Trolox, through its antioxidative capacity, buttresses α2-Macroglobulin's activity by mitigating oxidative stress. Ascorbic acid contributes to the maintenance of α2-Macroglobulin, ensuring its protease inhibition capability is uncompromised. Retinoic acid, via modulation of immune-related gene expression, and zinc sulfate, through its role as a structural cofactor, both serve to reinforce the protein's protease regulatory function. Selenium is pivotal in maintaining the protein's structure, thereby enhancing its binding affinity to proteases and cytokines.
Furthermore, N-Acetylcysteine (NAC) indirectly supports α2-Macroglobulin's protease inhibitory role by amplifying cellular antioxidative defenses. Silymarin ensures the protein's activity by shielding it from oxidative damage, thereby preserving its protease inhibition capacity. Likewise, lipoic acid sustains α2-Macroglobulin's activity by maintaining a reduced intracellular environment conducive to its function. Omega-3 fatty acids like EPA and DHA modulate cellular membrane composition and signaling processes, which could lead to a heightened expression or stability of α2-Macroglobulin. Through these varied but convergent mechanisms, these activators collectively enhance the functional activity of α2-Macroglobulin, ensuring its efficacy in its role as a protease inhibitor and mediator of the immune response without necessitating a direct increase in gene expression or translation.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol found in green tea that can enhance the anti-inflammatory response by inhibiting NF-κB, a transcription factor that regulates the expression of α2-Macroglobulin. By reducing NF-κB activity, EGCG can indirectly enhance the level and activity of α2-Macroglobulin as part of the inflammatory response. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a stilbenoid and an antioxidant that has been shown to increase the expression of α2-Macroglobulin by activating SIRT1. SIRT1 activation leads to the deacetylation of transcription factors that induce the expression of proteins involved in the antioxidant response, including α2-Macroglobulin. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a bioactive compound in turmeric with anti-inflammatory properties. It can enhance the activity of α2-Macroglobulin by inhibiting the transcription factor NF-κB, thereby reducing the expression of pro-inflammatory cytokines and indirectly increasing the regulatory role of α2-Macroglobulin in inflammation. | ||||||
Trolox | 53188-07-1 | sc-200810 sc-200810A sc-200810B sc-200810C sc-200810D | 500 mg 1 g 5 g 25 g 100 g | $37.00 $66.00 $230.00 $665.00 $1678.00 | 39 | |
Trolox is a water-soluble analog of vitamin E that can indirectly enhance the functional activity of α2-Macroglobulin through its antioxidant effects, reducing oxidative stress and thereby potentially increasing the stability and activity of α2-Macroglobulin. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic acid, or vitamin C, can contribute to the stabilization of α2-Macroglobulin by reducing oxidative damage. This can enhance the protein's ability to inhibit proteases and bind growth factors as part of its normal function in regulating protease activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, has been implicated in the modulation of protein functions related to the immune response. It may enhance α2-Macroglobulin activity by influencing the gene expression of proteins involved in the immune system, potentially increasing the functional availability of α2-Macroglobulin. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc acts as a cofactor for various enzymes and can stabilize the structure of proteins, including α2-Macroglobulin. By binding to α2-Macroglobulin, zinc can enhance its protease inhibitory activity, which is a key aspect of its function in protease regulation. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
Selenium, an essential trace element, can enhance the biological activity of α2-Macroglobulin by contributing to the proper conformation of the protein, which is necessary for its binding to proteases and cytokines. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
NAC is a precursor of glutathione, which plays a role in maintaining the redox state within cells. By enhancing the antioxidant capacity of cells, NAC can indirectly support the stability and activity of α2-Macroglobulin in its function as a protease inhibitor. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $319.00 | ||
Silymarin, the active component of milk thistle, has hepatoprotective and antioxidant properties. It can enhance the activity of α2-Macroglobulin by protecting it from oxidative damage, thus preserving its ability to inhibit proteases. | ||||||