α2-Macroglobulin Inhibitors
Chemical inhibitors of α2-Macroglobulin offer various mechanisms by which they can impede the protein's protease-binding function. E-64 is one such chemical that forms a covalent adduct with the active cysteine residue in the protease domain of α2-Macroglobulin, thereby causing an irreversible inhibition. Similarly, Estatin interacts with cysteine residues at the active site, obstructing the protease-binding ability of the protein. Phosphoramidon takes a different approach by targeting the metalloprotease active site, crucial for the interaction between proteases and α2-Macroglobulin, and blocks it to prevent binding. Marimastat and Ilomastat also inhibit the interaction with metalloproteases by binding to the protein's metalloprotease domain; however, they do so by interacting with the catalytic domain of matrix metalloproteases that are targets of α2-Macroglobulin.
On the other hand, Pepstatin A inhibits α2-Macroglobulin by binding to aspartic residues within the protease's active site, which are essential for the proteolytic cleavage of substrates. Leupeptin and Antipain, which are reversible inhibitors of serine and cysteine proteases, interact with the catalytic site of α2-Macroglobulin, preventing the hydrolysis of peptide bonds. Aprotinin and Gabexate mesilate, both of which are known to primarily inhibit serine proteases, bind to the active site of α2-Macroglobulin and inhibit its function. Bestatin, as an aminopeptidase inhibitor, prevents the degradation of peptide substrates by blocking access to α2-Macroglobulin's binding sites for proteolytic enzymes. Meanwhile, Chymostatin specifically binds to and blocks the chymotrypsin-like proteases that α2-Macroglobulin may target, thus inhibiting the protein's protease activity. Each chemical inhibitor utilizes a unique method to inhibit α2-Macroglobulin, resulting in the reduction of its functional proteolytic activity in various capacities.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
E-64 is a potent, irreversible cysteine protease inhibitor that can inhibit the proteolytic activity of α2-Macroglobulin by forming a covalent adduct with the active cysteine residue in the protease domain of the protein. | ||||||
Phosphoramidon | 119942-99-3 | sc-201283 sc-201283A | 5 mg 25 mg | $199.00 $632.00 | 8 | |
Phosphoramidon is a metalloprotease inhibitor that can inhibit the protease-binding function of α2-Macroglobulin by blocking the metalloprotease active site, which is necessary for the protein's interaction with proteases. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
Leupeptin is a reversible inhibitor of serine and cysteine proteases that inhibits the proteolytic function of α2-Macroglobulin by interacting with its catalytic site, preventing the hydrolysis of peptide bonds in proteins. | ||||||
Chymostatin | 9076-44-2 | sc-202541 sc-202541A sc-202541B sc-202541C sc-202541D | 5 mg 10 mg 25 mg 50 mg 100 mg | $156.00 $260.00 $640.00 $1186.00 $2270.00 | 3 | |
Chymostatin is a chymotrypsin inhibitor that can inhibit the protease activity of α2-Macroglobulin by specifically binding to and blocking the chymotrypsin-like proteases that α2-Macroglobulin may target. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $112.00 $408.00 $3000.00 | 51 | |
Aprotinin is a protease inhibitor that primarily inhibits serine proteases and can inhibit the protease-binding function of α2-Macroglobulin by preventing the interaction with various serine proteases. | ||||||
Bestatin | 58970-76-6 | sc-202975 | 10 mg | $131.00 | 19 | |
Bestatin is an aminopeptidase inhibitor that prevents the degradation of peptide substrates, and it can inhibit the protease activity of α2-Macroglobulin by blocking access to the binding sites for proteolytic enzymes. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Marimastat is a broad-spectrum matrix metalloprotease (MMP) inhibitor that can inhibit the protease activity of α2-Macroglobulin by binding to the protein's metalloprotease domain, preventing its interaction with various MMPs. | ||||||
Gabexate mesylate | 56974-61-9 | sc-215066 | 5 mg | $100.00 | ||
Gabexate mesilate is a serine protease inhibitor that can inhibit the protease activity of α2-Macroglobulin by binding to its active site, thereby obstructing the proteolytic processing of α2-Macroglobulin's target proteases. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
Ilomastat is a synthetic matrix metalloprotease inhibitor that can inhibit the function of α2-Macroglobulin by binding to the catalytic domain of MMPs which α2-Macroglobulin targets, thereby preventing the protease-protein complex formation. | ||||||