ALKBH4 Activators
ALKBH4 activators are a group of chemicals that, through various biochemical mechanisms, enhance the functional activity of the ALKBH4 enzyme. These activators do not directly bind to ALKBH4; instead, they influence the enzyme's activity by modulating cellular levels of substrates, cofactors, or associated metabolites necessary for optimal enzyme function. For instance, α-Ketoglutarate indirectly supports ALKBH4 by serving as a cofactor required for its demethylation reaction, while ascorbate assists in keeping iron in the reduced state, which is crucial for the catalytic activity of ALKBH4 and similar dioxygenase enzymes.
Furthermore, compounds like methionine indirectly increase ALKBH4 activity by modulating the substrate availability through metabolic feedback mechanisms. By influencing the levels of these compounds within the cell, one can infer an indirect regulatory role over ALKBH4 activity. It is worth noting that the actual presence and efficacy of such ALKBH4 activators in biological systems are based on the understanding of the enzyme's biochemistry and cellular functions, such as its role in DNA repair and the regulation of epigenetic marks. The precise modulation of ALKBH4 activity through these chemicals represents a nuanced approach to influencing cellular processes at the molecular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
α-Ketoglutarate is a key intermediate in the Krebs cycle that also serves as a cofactor for dioxygenase enzymes, such as ALKBH4. By ensuring the availability of α-ketoglutarate, its cellular concentration can indirectly enhance the dioxygenase activity of ALKBH4 by providing the necessary substrate for catalysis. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbate, commonly known as vitamin C, is a cofactor that maintains iron in a reduced state for optimal activity of dioxygenase enzymes. By promoting the reduction of iron, ascorbate can enhance the catalytic efficiency of ALKBH4, potentially increasing its demethylation activity on DNA and RNA substrates. | ||||||
DL-Methionine | 59-51-8 | sc-397777 | 100 g | $45.00 | ||
Methionine serves as a methyl donor in numerous methylation reactions. An increase in methionine levels could lead to hypermethylation of DNA substrates, which could in turn create more substrate availability for ALKBH4 and increase its activity in a feedback mechanism aiming to regulate methylation homeostasis. | ||||||
Ferrous Sulfate (Iron II Sulfate) Heptahydrate | 7782-63-0 | sc-211505 sc-211505A | 250 g 500 g | $73.00 $109.00 | ||
Iron(II) sulfate provides the ferrous iron required as a cofactor for the catalytic activity of AlkB family enzymes, including ALKBH4. Adequate levels of ferrous iron are essential for the hydroxylation reactions carried out by these enzymes, thus potentially increasing ALKBH4's enzymatic activity. | ||||||
Fumaric acid | 110-17-8 | sc-250031 sc-250031A sc-250031B sc-250031C | 25 g 100 g 500 g 2.5 kg | $43.00 $57.00 $114.00 $228.00 | ||
Fumarate, similar to succinate, acts as a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Its accumulation can inhibit the activity of these enzymes, leading to potential dysregulation of ALKBH4's normal enzymatic role in epigenetic and gene expression control mechanisms. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $37.00 $57.00 $151.00 $577.00 $1103.00 | ||
Methionine serves as a precursor in the methionine cycle, leading to the production of S-adenosylmethionine (SAM), the methyl donor for most methyltransferases. An increase in methionine may indirectly upregulate methyltransferase activity, which could result in a compensatory increase in ALKBH4 activity. | ||||||