AKR1B7 Activators

AKR1B7 Activators are a unique class of chemical compounds that can enhance the functional activity of AKR1B7 either directly or indirectly. The activators include flavonoids like quercetin and polyphenols like resveratrol, which enhance the enzymatic activity of AKR1B7 by increasing the cellular levels of NADPH, a key cofactor forAKR1B7 activity. Furthermore, isoprenoids like farnesol increase the concentration of isoprenoids in cells, leading to an upsurge in AKR1B7 activity which is directly involved in the metabolism of these compounds. Drugs such as acetaminophen, salicylic acid, and chlorpropamide, which are metabolized by AKR1B7, increase the enzyme's activity by providing more substrates for it to act upon.

In addition to these, AKR1B7 activators comprise of compounds that indirectly enhance the protein's activity by influencing related cellular processes. For instance, 5-aminolevulinic acid boosts the heme biosynthesis pathway, indirectly enhancing AKR1B7 activity, since the protein is involved in heme metabolism. Inhibitors like 17-AAG and tunicamycin that intensify the quantity of unfolded proteins in the cell indirectly enhance AKR1B7 activity, as the enzyme is involved in the cellular response to protein unfolding. Also, lipoxygenase inhibitors like zileuton and nordihydroguaiaretic acid enhance AKR1B7 activity by increasing cellular levels of arachidonic acid, a substrate for AKR1B7. In the same vein, ebselen, a selenium-based drug, enhances AKR1B7 activity by acting as a glutathione peroxidase mimetic, reducing oxidative stress, and thereby increasing the availability of NADPH, a cofactor required for AKR1B7 activity.