AKR1B7 Activators
AKR1B7 Activators are a unique class of chemical compounds that can enhance the functional activity of AKR1B7 either directly or indirectly. The activators include flavonoids like quercetin and polyphenols like resveratrol, which enhance the enzymatic activity of AKR1B7 by increasing the cellular levels of NADPH, a key cofactor forAKR1B7 activity. Furthermore, isoprenoids like farnesol increase the concentration of isoprenoids in cells, leading to an upsurge in AKR1B7 activity which is directly involved in the metabolism of these compounds. Drugs such as acetaminophen, salicylic acid, and chlorpropamide, which are metabolized by AKR1B7, increase the enzyme's activity by providing more substrates for it to act upon.
In addition to these, AKR1B7 activators comprise of compounds that indirectly enhance the protein's activity by influencing related cellular processes. For instance, 5-aminolevulinic acid boosts the heme biosynthesis pathway, indirectly enhancing AKR1B7 activity, since the protein is involved in heme metabolism. Inhibitors like 17-AAG and tunicamycin that intensify the quantity of unfolded proteins in the cell indirectly enhance AKR1B7 activity, as the enzyme is involved in the cellular response to protein unfolding. Also, lipoxygenase inhibitors like zileuton and nordihydroguaiaretic acid enhance AKR1B7 activity by increasing cellular levels of arachidonic acid, a substrate for AKR1B7. In the same vein, ebselen, a selenium-based drug, enhances AKR1B7 activity by acting as a glutathione peroxidase mimetic, reducing oxidative stress, and thereby increasing the availability of NADPH, a cofactor required for AKR1B7 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that can enhance the activity of AKR1B7 by increasing the substrate availability. This compound has the ability to reduce NADP+ to NADPH, which is a key cofactor for AKR1B7 activity. By increasing the cellular levels of NADPH, Quercetin indirectly enhances the enzymatic activity of AKR1B7. | ||||||
Farnesol | 4602-84-0 | sc-204748 sc-204748A | 50 ml 100 ml | $275.00 $367.00 | 2 | |
Farnesol is an isoprenoid that can enhance AKR1B7 activity by increasing the concentration of isoprenoids in the cell. AKR1B7 is involved in the metabolism of isoprenoids, and an increase in isoprenoid concentration can lead to an increase in AKR1B7 activity. | ||||||
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $82.00 $301.00 $362.00 $1229.00 | 8 | |
Zileuton is a 5-lipoxygenase inhibitor that can lead to an increase in AKR1B7 activity. By inhibiting 5-lipoxygenase, Zileuton can lead to an increase in cellular levels of arachidonic acid, a substrate for AKR1B7, thereby enhancing its activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a polyphenol that can enhance AKR1B7 activity by increasing cellular levels of NADPH. Resveratrol has been shown to increase NADPH levels in cells, thereby indirectly enhancing the enzymatic activity of AKR1B7. | ||||||
5-Aminolevulinic Acid Hydrochloride Salt | 5451-09-2 | sc-262399 sc-262399A sc-262399B sc-262399C | 1 g 5 g 25 g 100 g | $36.00 $206.00 $347.00 $1326.00 | 2 | |
5-Aminolevulinic acid is a precursor in the heme biosynthesis pathway that can lead to an increase in AKR1B7 activity. By increasing the concentration of heme, this compound indirectly enhances AKR1B7 activity, as AKR1B7 is involved in the metabolism of heme. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
17-AAG is an Hsp90 inhibitor that can indirectly enhance AKR1B7 activity. 17-AAG can lead to an increase in unfolded proteins, which can lead to an increase in AKR1B7 activity, as AKR1B7 is involved in the cellular response to protein unfolding. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin is an inhibitor of N-linked glycosylation that can lead to an increase in AKR1B7 activity. By increasing the amount of unfolded proteins in the cell, Tunicamycin indirectly enhances AKR1B7 activity, as AKR1B7 is involved in the cellular response to protein unfolding. | ||||||
Acetaminophen | 103-90-2 | sc-203425 sc-203425A sc-203425B | 5 g 100 g 500 g | $40.00 $60.00 $190.00 | 11 | |
Acetaminophen is a drug that is metabolized by AKR1B7. The presence of Acetaminophen can directly enhance AKR1B7 activity by providing more substrate for the enzyme to act upon. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $46.00 $92.00 $117.00 | 3 | |
Salicylic acid is a drug that is metabolized by AKR1B7. The presence of Salicylic acid can directly enhance AKR1B7 activity by providing more substrate for the enzyme to act upon. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $107.00 $376.00 $2147.00 | 3 | |
Nordihydroguaiaretic acid is a lipoxygenase inhibitor that can lead to an increase in AKR1B7 activity. By inhibiting lipoxygenase, Nordihydroguaiaretic acid can lead to an increase in cellular levels of arachidonic acid, a substrate for AKR1B7, thereby enhancing its activity. | ||||||