AGXT Activators
The chemical class of AGXT (Alanine-Glyoxylate Aminotransferase) activators comprises various compounds that modulate the activity of the AGXT enzyme, primarily involved in amino acid metabolism, particularly the conversion of glyoxylate to glycine in the liver. These activators can directly or indirectly influence AGXT function, impacting its role in maintaining metabolic balance within the body. Direct activators of AGXT include Pyridoxal Phosphate (PLP), which acts as a coenzyme, binding to AGXT's active site and facilitating its transaminase function, thereby promoting the conversion of glyoxylate into glycine. Glycine, a substrate for AGXT, directly activates the enzyme, further supporting the conversion of glyoxylate into glycine.
Indirect activators include compounds like Dicumarol, which inhibits vitamin K epoxide reductase, leading to reduced PLP levels and, consequently, decreased AGXT activity. L-Glutamine indirectly affects AGXT by providing nitrogen for amino acid metabolism, influencing the balance of various amino acids. Folic Acid participates indirectly in AGXT activation by its involvement in one-carbon metabolism and amino acid metabolic pathways. Niacin (Vitamin B3) indirectly activates AGXT through its role in cellular energy metabolism pathways related to amino acid metabolism. Dihydropteridine inhibitors indirectly influence AGXT by interfering with the tetrahydrobiopterin (BH4) pathway in amino acid metabolism. Ethanol indirectly affects AGXT by impacting cellular metabolic processes that may influence amino acid metabolism.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
PLP directly activates AGXT by binding to its active site, facilitating its transaminase function in amino acid metabolism. | ||||||
Pyridoxine Hydrochloride | 58-56-0 | sc-219674 | 10 mg | $42.00 | ||
Pyridoxine is a precursor to PLP, ensuring the production of the coenzyme that activates AGXT. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
Glycine, a substrate for AGXT, directly activates the enzyme, supporting glyoxylate-to-glycine conversion. | ||||||
Dicoumarol | 66-76-2 | sc-205647 sc-205647A | 500 mg 5 g | $20.00 $40.00 | 8 | |
Dicumarol indirectly affects AGXT by inhibiting vitamin K epoxide reductase, leading to reduced PLP levels and AGXT activity. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
H2O2 indirectly activates AGXT by promoting oxidative stress, potentially affecting AGXT expression or activity. | ||||||
L-Glutamine | 56-85-9 | sc-391013 sc-391013C sc-391013A sc-391013D sc-391013B | 100 g 250 g 1 kg 5 kg 10 kg | $37.00 $47.00 $99.00 $379.00 $733.00 | 2 | |
L-Glutamine indirectly influences AGXT by providing nitrogen for amino acid metabolism, affecting amino acid balance. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Folic acid indirectly impacts AGXT through its involvement in one-carbon metabolism and amino acid metabolic pathways. | ||||||