AGXT Antibody (173J2B): sc-517624
- AGXT Antibody (173J2B) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 188-375 of AGXT of human origin
- recommended for detection of AGXT of human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for AGXT Antibody (173J2B). This work is in progress.
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AGXT Antibody (173J2B) is a mouse monoclonal IgG1 antibody that detects AGXT in human samples through western blotting (WB). AGXT, also known as alanine-glyoxylate aminotransferase, is a 392 amino acid protein that plays a crucial role in amino acid metabolism, specifically in the transamination process that converts alanine and glyoxylate into pyruvate and glutamate. This enzymatic function is vital for maintaining metabolic balance and preventing the accumulation of toxic metabolites, which can lead to conditions such as hyperoxaluria primary type 1 (HP1). AGXT is primarily localized in the peroxisomes of liver cells, where AGXT facilitates the breakdown of amino acids and the detoxification of harmful compounds. AGXT′s homodimeric structure, which relies on pyridoxal phosphate as a cofactor, is essential for enzymatic activity, as AGXT allows for the proper binding and conversion of substrates. The significance of AGXT extends beyond metabolic functions, as mutations in the AGXT gene can result in severe health issues, underscoring the importance of AGXT in both normal physiology and disease states. Anti-AGXT antibody (173J2B) is an invaluable tool for researchers studying the role of AGXT in metabolic disorders and potential therapeutic targets.
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AGXT Antibody (173J2B) References:
- Alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting in human hereditary kidney stone disease. | Danpure, CJ., et al. 2003. Biochim Biophys Acta. 1647: 70-5. PMID: 12686111
- Human liver peroxisomal alanine:glyoxylate aminotransferase: characterization of the two allelic forms and their pathogenic variants. | Cellini, B., et al. 2011. Biochim Biophys Acta. 1814: 1577-84. PMID: 21176891
- Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure. | Caplin, B., et al. 2012. Arterioscler Thromb Vasc Biol. 32: 2892-900. PMID: 23023372
- Primary hyperoxaluria. | Lorenzo, V., et al. 2014. Nefrologia. 34: 398-412. PMID: 24798559
- Natural and Unnatural Compounds Rescue Folding Defects of Human Alanine: Glyoxylate Aminotransferase Leading to Primary Hyperoxaluria Type I. | Oppici, E., et al. 2016. Curr Drug Targets. 17: 1482-91. PMID: 26931357
- Alanine-glyoxylate aminotransferase 1 (AGXT1) is a novel marker for hepatocellular carcinomas. | Zhao, CL., et al. 2018. Hum Pathol. 80: 76-81. PMID: 29883780
- Systemic Alanine Glyoxylate Aminotransferase mRNA Improves Glyoxylate Metabolism in a Mouse Model of Primary Hyperoxaluria Type 1. | Kukreja, A., et al. 2019. Nucleic Acid Ther. 29: 104-113. PMID: 30676254
- Dimerization Drives Proper Folding of Human Alanine:Glyoxylate Aminotransferase But Is Dispensable for Peroxisomal Targeting. | Dindo, M., et al. 2021. J Pers Med. 11: PMID: 33917320
- Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling. | Rodionov, RN., et al. 2022. Sci Rep. 12: 9381. PMID: 35672381
- Variable peroxisomal and mitochondrial targeting of alanine: glyoxylate aminotransferase in mammalian evolution and disease. | Danpure, CJ. 1997. Bioessays. 19: 317-26. PMID: 9136629
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AGXT Antibody (173J2B) | sc-517624 | 100 µg/ml | $316.00 |