Aflatoxin B2 Inhibitors
Aflatoxin B2 inhibitors are a class of compounds that target and hinder the biosynthesis or function of aflatoxin B2, one of the toxic secondary metabolites produced by certain strains of the fungi Aspergillus flavus and Aspergillus parasiticus. These fungi are found in a variety of agricultural commodities, and their metabolites, especially aflatoxins, are a significant concern because of their potential threat to food safety. Aflatoxins, including aflatoxin B2, are known to be potent carcinogens and can have serious implications for health when ingested, even in small quantities. Aflatoxin B2, though less predominant than aflatoxin B1, still presents a significant risk due to its toxic nature. The study and identification of inhibitors for aflatoxin B2 is an active area of research aiming to ensure food safety and security by reducing or eliminating the contamination of food products.
The mode of action of these inhibitors varies. Some compounds work by interrupting the enzymatic pathways involved in aflatoxin B2 production, while others might inhibit the growth of the fungi itself or block the binding sites that facilitate aflatoxin production. These inhibitors can be found in various sources, including natural extracts from plants, microorganisms, or even chemically synthesized compounds. Researchers use a range of techniques, from molecular docking studies to in vivo testing, to identify and optimize these inhibitors. The effectiveness of an inhibitor is usually measured by its ability to reduce or prevent the production of aflatoxin B2 in fungal cultures or contaminated substrates. The ultimate goal in studying these compounds is to develop strategies for preventing or reducing aflatoxin contamination, thus ensuring the safety of agricultural products.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
A synthetic dithiolthione derivative. Oltipraz induces phase II detoxification enzymes which enhance the detoxification of aflatoxins. Additionally, it might suppress the activation of aflatoxin to its carcinogenic form by inhibiting certain cytochrome P450 enzymes. | ||||||
Ferulic acid | 1135-24-6 | sc-204753 sc-204753A sc-204753B sc-204753C sc-204753D | 5 g 25 g 100 g 500 g 1 kg | $42.00 $62.00 $153.00 $552.00 $988.00 | 10 | |
A hydroxycinnamic acid found in the cell walls of plants. Ferulic acid can modulate oxidative stress and inhibit the growth of aflatoxin-producing fungi, leading to reduced aflatoxin synthesis. | ||||||
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $565.00 $310.00 | ||
A major component of anise and fennel oils. Anethole has antifungal properties that suppress the growth of Aspergillus flavus, thereby limiting aflatoxin production. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
A phenolic compound found in clove oil. Eugenol demonstrates antifungal activity against Aspergillus species, hindering their growth and subsequent aflatoxin production. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
A compound responsible for the flavor and aroma of cinnamon. It exhibits antifungal properties against Aspergillus species, disrupting their growth and reducing aflatoxin synthesis. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
A major component of lemongrass oil. Citral shows antifungal activity against aflatoxin-producing fungi, which can limit their growth and toxin production. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
An amino acid derivative and antioxidant. NAC can chelate with the active moieties of aflatoxin, rendering them inactive. It also boosts cellular defense mechanisms against oxidative stress induced by aflatoxins. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $107.00 $376.00 $2147.00 | 3 | |
A lipoxygenase inhibitor found in the creosote bush. NDGA suppresses oxidative stress, which might influence aflatoxin synthesis pathways. Additionally, it inhibits fungal lipoxygenase, an enzyme associated with aflatoxin production. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
A polyphenolic compound found in various fruits and vegetables. It's believed that ellagic acid interferes with the enzymatic processes necessary for the production of aflatoxins. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
A sulfur-rich compound found in cruciferous vegetables. Sulforaphane induces phase II detoxification enzymes, which can neutralize the carcinogenic metabolites of aflatoxin. | ||||||