AFF4 Inhibitors
AFF4 inhibitors are a class of chemicals that target and modulate the activity of the AFF4 protein, a member of the AFF family known for its involvement in various cellular processes. AFF4, or AF4/FMR2 family member 4, is a transcriptional coactivator that plays a crucial role in regulating gene expression by interacting with other transcription factors and components of the transcriptional machinery. It is part of a complex network that influences cellular growth, differentiation, and development through its effects on gene expression.
The mechanism of action for AFF4 inhibitors involves binding to the AFF4 protein and altering its ability to interact with its partners in the transcriptional machinery. These inhibitors can be small molecules or peptides designed to specifically bind to AFF4, thereby disrupting its normal function. By inhibiting AFF4, these chemicals can influence the transcriptional activity of genes regulated by this protein. The modulation of AFF4's activity can lead to changes in gene expression profiles, affecting various biological processes. Research into AFF4 inhibitors provides insights into the function of AFF4 in cellular regulation and helps to elucidate the broader impact of transcriptional regulation on cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol is a CDK9 inhibitor, potentially affecting transcription elongation processes influenced by AFF4. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 inhibits the BET family of bromodomain proteins and may indirectly impact AFF4-mediated transcription regulation. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
I-BET151 is another BET bromodomain inhibitor, potentially influencing transcription processes involving AFF4. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide inhibits the RNA polymerase II-mediated transcription, potentially affecting AFF4's role in transcription elongation. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB is a transcription inhibitor that targets RNA Polymerase II, possibly affecting pathways involving AFF4. | ||||||
THZ1 | 1604810-83-4 | sc-507542 | 1 mg | $95.00 | ||
THZ1 is a covalent inhibitor of CDK7, which could indirectly affect transcriptional regulation by AFF4. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 is an NF-κB inhibitor, which could indirectly impact transcriptional pathways involving AFF4. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
Pladienolide B targets the spliceosome, potentially influencing transcription regulation and elongation processes related to AFF4. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Seliciclib, a CDK inhibitor, can potentially affect transcriptional elongation and processes in which AFF4 is involved. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 is a p300/CBP histone acetyltransferase inhibitor, potentially impacting transcription regulation involving AFF4. | ||||||