ADHα Activators
Alcohol dehydrogenase alpha (ADHα) is a pivotal enzyme in the metabolic processing of alcohols within the liver, playing a crucial role in the conversion of ethanol to acetaldehyde. This enzyme belongs to a group of dehydrogenases that facilitate the interconversion between alcohols and aldehydes or ketones with the reduction of NAD⁺ to NADH. The expression of ADHα is not static; it can be influenced by the presence of various substrates and environmental factors, which can lead to an increase in its synthesis and activity. The regulation of ADHα is a complex process, involving not only the direct presence of substrates but also feedback mechanisms and interactions with other cellular pathways.
A number of chemicals act as activators, inducing the expression of ADHα. Ethanol is one such activator; when ingested, it necessitates an enhanced metabolic response, leading to increased synthesis of ADHα to facilitate its breakdown. Methanol and isopropanol are also metabolized by ADHα, and their presence can signal the liver to upregulate the enzyme to aid in the detoxification process. Acetaldehyde, the primary metabolite of ethanol, can act in a feedback mechanism to stimulate the production of ADHα, ensuring efficient processing of this toxic substance. Non-alcoholic compounds such as retinoic acid have a role in inducing ADHα expression as well. Retinoic acid, through its interaction with nuclear receptors, can precipitate an increase in ADHα production, illustrating the enzyme's regulation by broader cellular signaling pathways. Other chemical agents, like sodium butyrate, can alter gene expression via epigenetic modifications, leading to the upregulation of ADHα. In the presence of certain heavy metals, like lead, the liver may also augment the production of ADHα, potentially as a protective response to mitigate their effects. Understanding the intricate network of interactions that lead to the upregulation of ADHα provides insight into how the body maintains homeostasis in the face of various chemical exposures.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Propanol | 67-63-0 | sc-391000C sc-391000 sc-391000B sc-391000A | 1 ml 25 ml 100 ml 500 ml | $32.00 $52.00 $62.00 $87.00 | 1 | |
Isopropanol metabolism through ADHα can signal the body to elevate ADHα production to efficiently convert it to acetone, thereby increasing the enzyme's overall activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can stimulate ADHα gene expression through its role as an active metabolite of vitamin A, binding to retinoic acid receptors which play a crucial role in the transcriptional activation of various metabolic processes. | ||||||
Fomepizole | 7554-65-6 | sc-252838 | 1 g | $74.00 | 1 | |
As an inhibitor of ADHα, Fomepizole can induce the liver to synthesize more ADHα in an attempt to counteract the inhibition, thereby promoting increased alcohol metabolism. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone can stimulate the hepatic transcription factors that elevate ADHα expression as part of its wide-ranging influence on the expression of genes involved in metabolic processes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate can lead to the upregulation of ADHα transcription by altering the chromatin structure around the ADHα gene, enhancing its accessibility to transcription machinery and thereby increasing its expression. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $83.00 | ||
Lead(II) acetate exposure may trigger a defense mechanism in the liver, resulting in the elevated expression of ADHα to potentially assist in mitigating the heavy metal's toxic effects through metabolic pathways. | ||||||
Chloroform | 67-66-3 | sc-239527A sc-239527 | 1 L 4 L | $110.00 $200.00 | 1 | |
Chloroform exposure can stimulate an increase in ADHα expression as the liver attempts to increase the capacity for metabolizing this solvent, reflecting an adaptive increase in detoxification enzyme levels. | ||||||
Benzene | 71-43-2 | sc-239290 | 1 L | $77.00 | ||
Benzene, by being a substrate for liver enzymes, can stimulate an increase in ADHα expression to facilitate its metabolism, thereby contributing to the detoxification process of this volatile organic compound. | ||||||