ADAM6B Activators
ADAM6B Activators include compounds that directly or indirectly enhance ADAM6B activity. BB-3103 is a selective direct activator inducing ectodomain shedding of key substrates like pro-HBEGF by activating ADAM6B's protease domain. Indirect activators influence inhibitory mechanisms. LY333531 prevents competitive suppression from ADAM17. Ro-32-0432 and Apicularen A, as PKC and PKMζ inhibitors, can respectively disinhibit ADAM6B from phosphorylation restraints.
Additional indirect activators modulate repressive pathways. SB431542 counters TGF-β inhibition of ADAM6B expression. VX-745, Nsc-87877 and AS602801 block IRAK, IKK and EphA2 control of transcription and substrate cleavage. Piceatannol and SB203580 may remove inhibitory phosphorylations or signaling. LY294002 interferes with PI3K regulation of substrate availability and suppression. Collectively, these Activators-whether directly targeting ADAM6B or interconnected restraints-optimize ADAM6B functionality without requiring overexpression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY-333,531 Hydrochloride | 169939-93-9 | sc-364215 sc-364215A | 1 mg 5 mg | $94.00 $287.00 | 6 | |
A selective TACE/ADAM17 inhibitor that can indirectly activate ADAM6B signaling by preventing competitive inhibition from ADAM17 for shared substrates. | ||||||
VX 745 | 209410-46-8 | sc-361401 sc-361401A | 10 mg 50 mg | $183.00 $842.00 | 4 | |
An IRAK1/4 inhibitor blocking NF-κB pathway repression of ADAM6B transcription normally mediated by IRAK kinases. | ||||||
NSC 87877 | 56990-57-9 | sc-204139 | 50 mg | $137.00 | 12 | |
An IKKβ inhibitor preventing IKKβ-dependent NF-κB pathway inhibition of ADAM6B. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
A tyrosine/serine-threonine kinase inhibitor removing inhibitory phosphorylations on ADAM6B to boost substrate cleavage. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A selective PI3K inhibitor interfering with PI3K pathways regulating ADAM6B substrate presentation/suppression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor potentially enhancing ADAM6B signaling by blocking p38's negative control of ADAM6B functions. | ||||||