ACOXL Activators
ACOXL Activators can be seen as encompassing a range of chemical activators that indirectly influence the metabolic processing of lipids and potentially upregulate the function of the ACOXL protein. The activators listed target various regulatory mechanisms within the cell. Some act by modulating nuclear receptors such as PPARs and LXRs. PPAR agonists like bezafibrate and fenofibrate increase the transcription of genes that are critical for the fatty acid oxidation process, thereby potentially upregulating the expression and activity of ACOXL.
Compounds that modulate AMPK activity, like AICAR and metformin, induce metabolic effects that include the upregulation of fatty acid oxidation pathways. This could also enhance the activity of ACOXL, which is postulated to be involved in these metabolic routes. Additionally, the activation of sirtuins by compounds like resveratrol through the elevation of NAD+ levels, as achieved by nicotinamide riboside supplementation, affects the cellular metabolic status, which might result in increased expression and functional activity of ACOXL. On a more complex regulatory level, rapamycin have the capacity to enact a broad metabolic shift toward enhanced fatty acid catabolism, within which ACOXL may be functionally active.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate is a PPAR agonist that can enhance the transcription of genes involved in fatty acid oxidation, potentially increasing the expression and activity of related enzymes such as ACOXL. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an AMP-activated protein kinase (AMPK) agonist. Activation of AMPK can lead to an upregulation of fatty acid oxidation pathways, potentially augmenting ACOXL activity. | ||||||
Montelukast Sodium | 151767-02-1 | sc-202231 sc-202231A sc-202231B | 10 mg 25 mg 250 mg | $51.00 $85.00 $161.00 | 5 | |
Montelukast acts on leukotriene pathways, which may intersect with lipid metabolism pathways and indirectly enhance the expression of fatty acid metabolism proteins, including ACOXL. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate is another PPARα agonist that can stimulate the peroxisomal β-oxidation pathway, potentially leading to increased ACOXL activity. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $82.00 $179.00 | 28 | |
GW501516 activates PPARδ, which has been shown to upregulate genes involved in fatty acid metabolism, possibly including ACOXL. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences gene expression via retinoic acid receptors, which can interact with PPARs and potentially increase the expression of ACOXL. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates sirtuins, which are involved in the regulation of metabolism and can induce the expression of genes related to fatty acid oxidation, potentially affecting ACOXL. | ||||||
GW 3965 hydrochloride | 405911-17-3 | sc-224011 sc-224011A sc-224011B | 5 mg 25 mg 1 g | $140.00 $483.00 $3121.00 | ||
GW3965 activates liver X receptors (LXR), which regulate the expression of genes involved in lipid metabolism, potentially affecting ACOXL levels. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide riboside can elevate NAD+ levels, which is a substrate for sirtuins. The activation of sirtuins can modulate the metabolic pathways, influencing ACOXL. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Although primarily an inhibitor, rapamycin can induce complex metabolic adjustments that enhance the catabolism of fatty acids, possibly involving ACOXL. | ||||||