ACOT6 Activators
ACOT6 activators employ diverse biochemical mechanisms to augment the enzyme's activity in lipid metabolism. Certain activators enhance intracellular cyclic AMP (cAMP) levels, which in turn activates protein kinase A. This kinase phosphorylates transcription factors that elevate ACOT6 expression and its enzymatic activity. In addition, the intracellular concentration of ACOT6 substrates is increased by other activators, which directly stimulates ACOT6 by providing more molecules for hydrolysis. This leads to the allosteric activation of ACOT6, enhancing its capacity to catalyze the breakdown of fatty acyl-CoA thioesters.
Additionally, activators that inhibit enzymes responsible for fatty acid transport into mitochondria lead to an accumulation of acyl-CoAs, which in turn indirectly increases the activity of ACOT6 as it works to hydrolyze these substrates. Moreover, specific compounds known to elevate NAD+ levels can activate sirtuins, which may deacetylate and activate transcription factors that upregulate ACOT6. Agonists of peroxisome proliferator-activated receptors further contribute to the transcriptional upregulation of ACOT6, leading to an increase in enzyme expression and subsequent rise in its metabolic activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, which increases cAMP levels in cells. Elevated cAMP activates PKA, which can phosphorylate transcription factors that increase the expression and activity of ACOT6. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP. The resulting increase in cAMP levels can enhance PKA activity, leading to upregulation and enhanced activity of ACOT6. | ||||||
Oleoyl coenzyme A | 1716-06-9 | sc-286621 sc-286621A | 5 mg 25 mg | $230.00 $939.00 | ||
Oleoyl-CoA is a natural substrate for ACOT6. The presence of high levels of oleoyl-CoA can stimulate the ACOT6 activity by providing more substrate for the enzyme to act upon. | ||||||
(+)-Etomoxir sodium salt | 828934-41-4 | sc-215009 sc-215009A | 5 mg 25 mg | $148.00 $496.00 | 3 | |
(R)-(+)-Etomoxir inhibits carnitine palmitoyltransferase 1 (CPT1), leading to an accumulation of acyl-CoAs. This accumulation can indirectly increase the activity of ACOT6 as it works to hydrolyze the excess acyl-CoAs. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that resists degradation by phosphodiesterases. Its accumulation in the cell can activate PKA, which then may enhance the expression and activity of ACOT6 through phosphorylation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), which can lead to the phosphorylation of transcription factors that enhance the expression of ACOT6, thereby increasing its enzymatic activity. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide riboside enhances NAD+ biosynthesis, which can activate sirtuins. Sirtuins may deacetylate and activate transcription factors that increase ACOT6 expression and activity. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate is an agonist of peroxisome proliferator-activated receptor alpha (PPARα), which can upregulate the expression of genes involved in fatty acid oxidation, including ACOT6, thus increasing its enzymatic activity. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone is a PPARγ agonist that can induce the transcription of genes involved in lipid metabolism. Activation of PPARγ may lead to increased expression and activity of ACOT6. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate activates PPARs, including PPARα. This activation can lead to the transcriptional upregulation of ACOT6, resulting in an increase in its enzymatic activity. | ||||||