ACOT4 Inhibitors

Peroxisomal Succinyl-Coenzyme A Thioesterase (ACOT4) inhibitors listed here target metabolic pathways and enzyme activities related to fatty acid metabolism and acyl-CoA processing, indirectly affecting ACOT4's function. Triacsin C Solution in DMSO, an inhibitor of long-chain acyl-CoA synthetase, can reduce the availability of substrates for ACOT4, indirectly modulating its activity. Perhexiline, (+)-Etomoxir sodium salt, and carnitine palmitoyltransferase inhibitors like Malonyl-CoA affect fatty acid oxidation pathways, which are closely related to ACOT4's role. Fibrate compounds such as Gemfibrozil, Fenofibrate, and Bezafibrate modulate lipid metabolism, potentially impacting pathways involving ACOT4. These compounds are known for their ability to influence lipid processing and metabolism.

Metformin, widely used in diabetes research, modulates metabolic pathways and could indirectly influence ACOT4's enzymatic activity. Nicotinic Acid, known for its effects on lipid metabolism, might have an indirect impact on ACOT4's function. L-Carnitine, important in fatty acid transport, could influence metabolic pathways associated with ACOT4. AICAR, an activator of AMP-activated protein kinase, is included for its role in regulating metabolism, potentially impacting pathways related to ACOT4's function. In summary, targeting ACOT4 involves modulating lipid metabolism and fatty acid processing pathways. The inhibitors listed, by affecting these metabolic pathways, offer potential routes to indirectly influence ACOT4's activity, considering its role in hydrolyzing acyl-CoAs and regulating intracellular levels of free fatty acids and CoASH.