ACAD-8 Inhibitors
ACAD-8 inhibitors represent a class of chemical compounds that specifically inhibit the activity of acyl-CoA dehydrogenase family member 8 (ACAD-8), an enzyme involved in fatty acid metabolism. ACAD-8 plays a role in the β-oxidation of branched-chain fatty acids and amino acids, including the degradation of isoleucine. This enzyme is located in the mitochondria, where it catalyzes the initial step in the breakdown of certain fatty acyl-CoA derivatives, producing enoyl-CoA intermediates. By inhibiting ACAD-8, these inhibitors can modulate metabolic pathways, particularly affecting the oxidation processes of specific branched-chain compounds. Structurally, ACAD-8 inhibitors are designed to target the active site of the enzyme, where they interfere with the binding of substrates, leading to reduced catalytic efficiency.
The inhibition of ACAD-8 alters mitochondrial fatty acid oxidation, leading to accumulation of branched-chain acyl-CoAs and potentially impacting cellular bioenergetics. Structurally, many ACAD-8 inhibitors are small molecules that interact with the enzyme's flavin adenine dinucleotide (FAD)-dependent catalytic mechanism, altering the electron transfer required for oxidation reactions. These inhibitors provide useful tools in research to study the enzymatic pathways involved in fatty acid metabolism and to understand how metabolic imbalances can affect mitochondrial function. Additionally, ACAD-8 inhibitors have been employed to explore the role of branched-chain amino acids and their degradation intermediates in various biochemical pathways, offering insight into how different forms of acyl-CoA dehydrogenases function within mitochondrial oxidative metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A may repress ACAD-8 expression by increasing histone acetylation, leading to the inaccessibility of transcriptional activators to the ACAD-8 gene promoter. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound could induce hypomethylation of the ACAD-8 gene promoter, potentially resulting in the recruitment of repressive transcriptional complexes that downregulate ACAD-8 expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid may lead to the hyperacetylation of histone proteins surrounding the ACAD-8 gene, thereby altering chromatin compaction and reducing the initiation of ACAD-8 transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, Sodium Butyrate could cause chromatin relaxation around the ACAD-8 gene, which may decrease the binding of transcription factors necessary for ACAD-8 expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A binds to GC-rich regions of DNA and could competitively inhibit the binding of transcription factors to the ACAD-8 promoter sequence, leading to a decrease in ACAD-8 gene expression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram's chelation of copper ions may attenuate the activity of copper-dependent transcription factors that are essential for the transcriptional initiation of the ACAD-8 gene, thereby reducing its expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid may downregulate ACAD-8 expression by binding to its retinoic acid response elements in the ACAD-8 gene promoter, altering the recruitment of co-repressors to the DNA segment. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea can deplete nucleotide pools, possibly leading to replication stress and the subsequent downregulation of ACAD-8 expression as part of a global response to DNA damage. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid may hinder ACAD-8 expression by preventing the deacetylation of histones, which could obstruct the chromatin remodeling necessary for the ACAD-8 gene's active transcription. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2′-Deoxycytidine could lead to reduced expression of ACAD-8 by inhibiting DNA methyltransferase, which might result in a transcriptionally inactive chromatin state at the ACAD-8 gene locus. | ||||||