ABO Blood Group Antigens Activators
The ABO Blood Group Antigen system is a classification scheme for human blood based on the presence or absence of specific antigens on the surface of red blood cells. These antigens are complex carbohydrates, specifically glycolipids and glycoproteins, that interact with corresponding antibodies in the plasma. The ABO system has four primary blood types: A, B, AB, and O, which are determined by the type of antigen displayed on the surface of the red blood cells. Type A blood has A antigens, Type B has B antigens, Type AB has both A and B antigens, and Type O has neither. The H antigen is produced by a specific fucosyltransferase. Depending upon a person's ABO blood type, the H antigen is converted into either the A antigen, B antigen, or both. If a person has blood group O, the H antigen remains unmodified. These antigens are synthesized by a series of enzymatic reactions involving glycosyltransferases that add sugar moieties to precursor molecules. The genetic basis for this system lies in the ABO gene, which encodes the glycosyltransferase enzyme responsible for the addition of specific carbohydrate residues, thereby determining the blood type.
ABO Blood Group Antigens Activators is a chemical class of molecules that can indirectly influence the activity or expression of ABO blood group antigens. These activators function via various mechanisms, such as by serving as substrate precursors for the biosynthesis of the antigens, by modifying epigenetic regulation, or by affecting complex cellular signaling pathways. For instance, molecules like GDP-Fucose and UDP-Galactose act as donor substrates for the glycosyltransferases that are involved in the biosynthesis of ABO antigens. Other molecules like Hydroxychloroquine, Ibuprofen, and various statins can indirectly modulate the cellular mechanisms that underlie the expression or modification of ABO blood group antigens.
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Items 1 to 10 of 13 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
UDP-α-D-Galactose disodium salt | 137868-52-1 | sc-286849 sc-286849A | 10 mg 50 mg | $104.00 $198.00 | 1 | |
A key donor substrate for galactosyltransferases involved in the biosynthesis of ABO group antigens. | ||||||
N-Acetyl-D-glucosamine | 7512-17-6 | sc-286377 sc-286377B sc-286377A | 50 g 100 g 250 g | $94.00 $162.00 $306.00 | 1 | |
A substrate for the initial glucosaminyl residues in glycan chains relevant to ABO group antigens. | ||||||
N-Acetyl-D-galactosamine | 1811-31-0 | sc-221979 sc-221979A sc-221979C sc-221979B sc-221979D | 10 mg 100 mg 1 g 5 g 50 g | $51.00 $77.00 $267.00 $1040.00 $1326.00 | ||
When introduced to cells, it can potentially increase the O-GalNAc type glycosylation, which might have implications for ABO group antigen expression. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Primarily an antimalarial drug, it affects endosomal acidification and could potentially affect glycan processing related to ABO group structures. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $53.00 $88.00 | 6 | |
Widely used for pain relief and inflammation, it inhibits COX-1 and COX-2 enzymes, which could potentially affect cellular signaling related to glycosylation patterns, including those of ABO group antigens. | ||||||
Naproxen | 22204-53-1 | sc-200506 sc-200506A | 1 g 5 g | $24.00 $41.00 | ||
Another common NSAID that could potentially have similar effects on glycosylation via COX inhibition, which might impact ABO group antigens. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Besides inhibiting COX enzymes, aspirin also has other complex effects on cell signaling and could theoretically influence ABO group antigen activity. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Used for treating various inflammatory diseases, it could affect prostaglandin levels and thereby have secondary effects on glycosylation patterns, including those relevant to ABO group antigens. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
One of the most commonly prescribed statins, it could potentially influence glycosylation through its effects on cellular metabolism, which might affect ABO group structures. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Known for its cholesterol-lowering effects, it may also affect cellular signaling pathways that could indirectly influence glycosylation, including that of ABO group antigens. | ||||||