ABCD4 Activators
ABCD4 Activators are a broad group of chemical entities that indirectly stimulate the function of the ATP-binding cassette sub-family D member 4, a protein crucial for moving various substances across cell membranes. These activators achieve their effects not by direct interaction with ABCD4 but through influencing other proteins and cellular mechanisms linked to ABCD4's performance. Glyburide and similar sulfonylureas, for instance, may boost ABCD4 by inhibiting related ABC transporters, creating a compensatory rise in its activity. Compounds like Probenecid and Indomethacin are also noted for hindering other transporters and anion channels, which might clear the way for ABCD4 substrates or pathways, thus amplifying its functional capacity. Adding to this, immunosuppressants and calcium channel blockers such as Cyclosporin A and Verapamil are known to suppress various ABC transporters, potentially diminishing competition and indirectly upregulating ABCD4's function. Cyclosporin A might inadvertently benefit ABCD4 by lessening the typical competitive inhibition among transporters, while Verapamil might allow ABCD4 to operate more efficiently by reducing substrate competition.
Concurrently, Elacridar and Tariquidar, which target P-glycoprotein, could favor ABCD4 activity by shifting the cellular transport balance in its favor. Furthermore, the interaction of NSAIDs like Ibuprofen and proton pump inhibitors like Omeprazole with ABC transporters may change cellular dynamics or conditions conducive to ABCD4 activity, such as Omeprazole's potential to modify intracellular pH. Moreover, Nicardipine's role in calcium channel inhibition, which impacts ABC transporters, may indirectly enhance ABCD4's capacity by lessening resource competition. Collectively, ABCD4 Activators utilize various indirect pathways to bolster ABCD4 function, including reducing competition with similar transporters, modifying cellular states to benefit ABCD4, or other indirect actions leading to increased ABCD4 transport activity.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $46.00 $61.00 $117.00 $173.00 $530.00 | 36 | |
Glyburide is a sulfonylurea compound that primarily acts on pancreatic beta cells to increase insulin secretion. It also inhibits the ABC transporter subfamily C member 8 (ABCC8). Since ABCD4 is an ABC transporter, glyburide’s inhibition of similar transporters may enhance activity of ABCD4 by a compensatory mechanism in cells where both are expressed. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $28.00 $39.00 $100.00 $277.00 | 28 | |
Probenecid is an inhibitor of various anion transporters. By inhibiting competitive or related transport pathways, probenecid could enhance the functional activity of ABCD4 by reducing substrate competition, allowing ABCD4 to function more effectively. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is well-known for its immunosuppressive properties, which are mediated through the inhibition of calcineurin. It also inhibits certain ABC transporters. Its broad action on ABC transporters may upregulate ABCD4 activity indirectly by decreasing competitive inhibition among ABC transporters. | ||||||
Elacridar | 143664-11-3 | sc-207613A sc-207613 sc-207613B sc-207613C sc-207613D | 5 mg 10 mg 50 mg 100 mg 1 g | $98.00 $113.00 $411.00 $525.00 $2606.00 | 19 | |
Elacridar is an inhibitor of P-glycoprotein and breast cancer resistance protein, both of which are ABC transporters. Inhibition of these transporters could shift cellular transporter activity towards ABCD4, potentially enhancing its function. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil, a calcium channel blocker, is also known to inhibit certain ABC transporters, such as P-glycoprotein. The inhibition of these transporters could indirectly increase the functional activity of ABCD4 by reducing transporter competition. | ||||||
MK-571 | 115103-85-0 | sc-201340 sc-201340A | 5 mg 25 mg | $109.00 $421.00 | 8 | |
MK-571 is a selective leukotriene receptor antagonist which also acts as an inhibitor of the multidrug resistance-associated protein 1 (MRP1), an ABC transporter. This specific inhibition could enhance ABCD4 function by freeing up cellular resources or reducing competitive interactions. | ||||||
Nitrofurantoin | 67-20-9 | sc-212399 | 10 g | $84.00 | ||
Nitrofurantoin has been shown to interact with ABC transporters, and its action could indirectly enhance ABCD4 by inhibiting other transporters in the family, thereby decreasing the competition for substrates or cellular resources. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that has been shown to inhibit certain ABC transporters. This inhibition could enhance ABCD4 activity by decreasing competition among ABC transporters for substrates. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $53.00 $88.00 | 6 | |
Ibuprofen, another NSAID, has effects on various transporters and could enhance ABCD4 activity by inhibiting the function of other ABC transporters, thus potentially increasing ABCD4 functional activity through reduced competition. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Omeprazole is a proton pump inhibitor that affects the pH within cellular compartments. By altering intracellular pH, it could modulate the activity of pH-sensitive transporters such as ABCD4, indirectly enhancing its activity. | ||||||