ABCB7 Inhibitors
ABCB7 inhibitors consist of a diverse group of chemical entities that indirectly attenuate the functional activity of ABCB7 by modulating various biochemical pathways integral to its operation. Oligomycin A and Agaric Acid, by targeting the mitochondrial ATP synthase and F-type ATPase, curtail the energy supply critical for ABCB7's role in iron-sulfur cluster assembly, a process that is reliant on ATP. Buthionine Sulfoximine lowers the cellular defense against oxidative stress by inhibiting glutathione synthesis, which is intricately connected to ABCB7's role in maintaining iron homeostasis and mitigating iron-induced oxidative damage. Ciclopirox Olamine and Mimosine exert their inhibitory effects through iron chelation, thereby impeding ABCB7's substrate availability and consequently its function in iron-sulfur cluster biogenesis. Similarly, Tiron's antioxidant properties and its metal-chelating capacity lead to a reduction in available iron, essential for ABCB7's function.
Moreover, compounds such as Stavudine and Auranofin, by disrupting mitochondrial DNA replication and inhibiting thioredoxin reductase, respectively, indirectly influence ABCB7's activity by altering mitochondrial function and the cellular redox state, which are vital for the integrity and transfer of iron-sulfur clusters. Retinoic Acid, by impacting cell differentiation and proliferation, can affect the energy-dependent processes associated with ABCB7, while Zileuton, through the modulation of the 5-lipoxygenase pathway, alters the cellular redox balance, which is closely related to mitochondrial function and the biosynthesis of iron-sulfur clusters. Alloxan and Sodium orthovanadate, by selectively destroying insulin-producing cells and inhibiting phosphatases, respectively, create an environment of disrupted cellular energy and signaling balance, affecting the function of ABCB7. Collectively, these inhibitors, through their targeted biochemical actions, contribute to the functional inhibition of ABCB7 by indirectly disrupting the cellular processes and pathways it is associated with.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
Oligomycin A is an inhibitor of the mitochondrial ATP synthase. ABCB7 is involved in the biogenesis of iron-sulfur clusters, a process that is dependent on mitochondrial ATP. By inhibiting ATP synthase, Oligomycin A indirectly decreases the energy supply necessary for ABCB7 function. | ||||||
Agaric acid | 666-99-9 | sc-210767 | 1 g | $816.00 | ||
Agaric Acid acts as an inhibitor of the F-type ATPase, which plays a role in producing mitochondrial ATP. Lower ATP levels would reduce the efficacy of ABCB7's iron-sulfur cluster assembly and export functions due to decreased energy availability for these energy-dependent processes. | ||||||
L-Buthionine sulfoximine | 83730-53-4 | sc-200824 sc-200824A sc-200824B sc-200824C | 500 mg 1 g 5 g 10 g | $280.00 $433.00 $1502.00 $2917.00 | 26 | |
Buthionine Sulfoximine is an inhibitor of glutathione synthesis by inhibiting γ-glutamylcysteine synthetase. Glutathione is crucial for cellular defense against oxidative stress, and ABCB7 is implicated in protecting cells from oxidative damage by regulating iron homeostasis and preventing iron accumulation. | ||||||
Ciclopirox | 29342-05-0 | sc-217893 | 25 mg | $207.00 | 2 | |
Ciclopirox Olamine chelates iron ions, reducing the available iron for cellular processes. ABCB7 is essential for iron homeostasis and by chelating iron, Ciclopirox Olamine can indirectly disrupt the function of ABCB7 by limiting its substrate availability. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $150.00 $210.00 $1899.00 | 39 | |
Auranofin inhibits the enzyme thioredoxin reductase, which is crucial for maintaining the redox balance in cells. The redox state is essential for the proper functioning of iron-sulfur cluster assembly, and thus ABCB7, as it can affect the integrity and transfer of these clusters. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $35.00 $86.00 $216.00 $427.00 | 8 | |
Mimosine chelates iron and inhibits DNA synthesis. By chelating iron, it reduces the availability of iron necessary for iron-sulfur cluster assembly, indirectly affecting ABCB7's function in the process. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid can influence the differentiation and proliferation of cells. These processes are highly regulated and energy-dependent, which could affect the mitochondrial function and thus the activity of ABCB7, which is critical for mitochondrial iron homeostasis. | ||||||
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $82.00 $301.00 $362.00 $1229.00 | 8 | |
Zileuton is a 5-lipoxygenase inhibitor and by affecting this pathway, it alters the cellular redox state. Changes in redox balance can influence mitochondrial function and the biosynthesis of iron-sulfur clusters where ABCB7 plays a crucial role. | ||||||
Alloxan monohydrate | 2244-11-3 | sc-254940 | 10 g | $53.00 | ||
Alloxan selectively destroys insulin-producing cells in the pancreas. This destruction leads to decreased ATP production due to a lower population of cells contributing to metabolism, indirectly impacting ABCB7 function by reducing the overall energy status required for its activity. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate is a phosphatase inhibitor that can disrupt multiple signaling pathways, potentially affecting the energy balance and redox state of the cell. These disruptions can indirectly influence the activity of ABCB7, which is dependent on these cellular states for its function. | ||||||