A730037C10Rik Inhibitors
Chemical inhibitors of coiled-coil domain containing 169 (CCDC169) include a range of compounds that disrupt microtubule dynamics, a crucial component for the intracellular transport and proper localization necessary for the protein's function. Colchicine, by binding to tubulin, inhibits its polymerization into microtubules, thereby directly disrupting the cytoskeletal organization and cell division processes. This inhibition affects the intracellular transport mechanisms, which are essential for the localization and function of CCDC169. Similarly, Vinblastine and Podophyllotoxin bind to tubulin and inhibit microtubule formation, which can lead to an altered cellular logistics and protein trafficking, thereby inhibiting CCDC169. The action of Nocodazole, which disrupts microtubule polymerization, and Vincristine, which prevents microtubule assembly, also contribute to the inhibition of CCDC169 by interfering with microtubule-dependent processes.
Furthermore, stabilizing microtubules excessively, as Paclitaxel does, can also inhibit CCDC169 by disrupting the normal microtubule dynamics necessary for the protein's transport and spatial organization within the cell. Griseofulvin, by binding to tubulin, impedes the microtubule-based transport and structural integrity, influencing the function of CCDC169. Eribulin's unique mechanism of inhibiting microtubule growth without affecting shortening contributes to disrupting the dynamic instability of microtubules, which is crucial for CCDC169's proper localization and function. Albendazole, Mebendazole, Thiabendazole, and Parbendazole, all of which target tubulin and microtubule synthesis, disrupt the cytoskeletal structures and intracellular transport systems that are essential for the function of CCDC169. This disruption, caused by the inhibition of microtubule polymerization, impacts the cellular processes and transport mechanisms vital for the activity of CCDC169.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization into microtubules, which disrupts cytoskeletal organization and cell division. As microtubules are crucial for intracellular transport, colchicine can inhibit the function of coiled-coil domain containing 169 (CCDC169) by disrupting the transport mechanisms necessary for its localization and function. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which can inhibit CCDC169 function by disrupting normal microtubule dynamics necessary for the protein's transport and spatial organization within the cell. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin, inhibiting microtubule formation. This inhibition can disrupt the intracellular transport routes, potentially leading to an inhibition of CCDC169 function due to altered cellular logistics and protein trafficking. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, potentially inhibiting CCDC169's function by altering the microtubule network required for its proper localization and activity. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin binds to tubulin and inhibits microtubule polymerization, which can inhibit CCDC169 by preventing the proper cellular organization and transport mechanisms needed for its activity. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin and can inhibit CCDC169 by impeding the microtubule-based transport and structural integrity necessary for the protein's function. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits microtubule growth without affecting shortening, potentially inhibiting CCDC169 by disrupting the dynamic instability of microtubules crucial for its proper localization and function within the cell. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $213.00 | 1 | |
Albendazole inhibits microtubule polymerization, which can inhibit the function of CCDC169 by disrupting the cytoskeletal structures needed for its transport and localization. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $46.00 $89.00 | 2 | |
Mebendazole disrupts microtubule synthesis, which can inhibit CCDC169 by disrupting essential intracellular transport routes and the structural framework required for the protein's function. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
Thiabendazole inhibits microtubule assembly, potentially inhibiting CCDC169 by impairing the cytoskeletal structures and intracellular transport systems necessary for its activity. | ||||||