A230051G13Rik Inhibitors
Chemical inhibitors of IBA57 homolog, iron-sulfur cluster assembly protein, utilize various mechanisms to disrupt the protein's function, which is critical in the assembly of iron-sulfur (Fe-S) clusters. Aurintricarboxylic Acid, for example, chelates iron, preventing the metal's incorporation into Fe-S clusters, which are essential for the activity of IBA57 homolog. Similarly, Sodium Metabisulfite interacts with iron to hinder Fe-S cluster biosynthesis, thereby impairing the function of IBA57 homolog. Hydrogen Sulfide alters cellular sulfur levels, which is crucial for Fe-S cluster synthesis, and its modulation of sulfur can inhibit the formation of these clusters necessary for IBA57 homolog activity. Cupric Sulfate and Stannous Chloride exert their inhibitory effects by binding sulfur and altering the redox state of iron, respectively, both of which are detrimental to the proper assembly of Fe-S clusters, leading to the inhibition of IBA57 homolog.
Additional chemicals disrupt Fe-S cluster assembly by targeting other elements of the biogenesis pathway. Methylglyoxal can modify lipoic acid, a cofactor for enzymes involved in Fe-S cluster assembly, thus disrupting IBA57 homolog function. Arsenic Trioxide impedes thioredoxin reductase, another enzyme necessary for the assembly process, thereby inhibiting IBA57 homolog. D-Penicillamine chelates metal ions, including those critical for Fe-S cluster formation, which is essential for IBA57 homolog activity. Nitric Oxide disrupts Fe-S cluster integrity by reacting with iron, thus inhibiting IBA57 homolog. Cadmium Chloride and Zinc Sulfate compete with iron for binding to sulfur, disrupting Fe-S cluster assembly and inhibiting IBA57 homolog. Lead(II) Acetate's binding to thiol groups and displacement of iron in Fe-S clusters directly inhibits the function of IBA57 homolog. Together, these chemicals target the intricate process of Fe-S cluster assembly, which is fundamental to the activity of IBA57 homolog, by interrupting the availability of essential metals, altering the redox environment, or chelating critical cofactors and metals.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aurintricarboxylic Acid | 4431-00-9 | sc-3525 sc-3525A sc-3525B sc-3525C | 100 mg 1 g 5 g 10 g | $20.00 $32.00 $48.00 $94.00 | 13 | |
Inhibits the assembly of iron-sulfur clusters by chelating iron, thus blocking IBA57 homolog's functional activity. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Binds to sulfur, potentially inhibiting iron-sulfur cluster formation and thus IBA57 homolog activity. | ||||||
Methylglyoxal solution | 78-98-8 | sc-250394 sc-250394A sc-250394B sc-250394C sc-250394D | 25 ml 100 ml 250 ml 500 ml 1 L | $146.00 $437.00 $478.00 $754.00 $1446.00 | 3 | |
Can modify lipoic acid, a cofactor necessary for iron-sulfur cluster assembly enzymes, inhibiting IBA57 homolog. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Interferes with thioredoxin reductase, an enzyme required for iron-sulfur cluster assembly, thus inhibiting IBA57 homolog. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
Chelates metal ions critical for iron-sulfur cluster formation, disrupting IBA57 homolog's function. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Competitively inhibits the incorporation of necessary metals into iron-sulfur clusters, thus inhibiting IBA57 homolog. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $85.00 | ||
Binds to thiol groups and can displace iron in iron-sulfur clusters, inhibiting IBA57 homolog function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Competes with iron for binding to sulfur, possibly disrupting cluster assembly and thus inhibiting IBA57 homolog. | ||||||