MEK-5 Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BIX 02189 | 1094614-85-3 | sc-364436 sc-364436A | 5 mg 10 mg | $224.00 $386.00 | 5 | |
BIX 02189 acts as a selective MEK-5 inhibitor, distinguished by its capacity to engage in hydrogen bonding and hydrophobic interactions with the target enzyme. This compound demonstrates a unique competitive inhibition mechanism, effectively altering substrate binding dynamics. Kinetic studies indicate a rapid association rate, contributing to its efficacy in modulating downstream signaling pathways. Its polar functional groups enhance solubility, promoting bioavailability in various environments. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is another well-known inhibitor of MEK1/2. Similar to PD0325901, it can have off-target effects on other MEK proteins, potentially including MEK-5, due to the similarity in their kinase domains. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $114.00 $166.00 $947.00 | 19 | |
Trametinib is a selective inhibitor of MEK1/2. Its inhibitory effects on these kinases can indirectly influence MEK-5 activity, particularly in cellular contexts where multiple MEK isoforms interact or have compensatory roles. | ||||||
Cobimetinib | 934660-93-2 | sc-507421 | 5 mg | $270.00 | ||
Cobimetinib targets MEK1/2, and by modulating the activity of these closely related kinases, it might indirectly affect MEK-5, especially in signaling pathways where there is functional redundancy or interaction between different MEK isoforms. | ||||||
Selumetinib | 606143-52-6 | sc-364613 sc-364613A sc-364613B sc-364613C sc-364613D | 5 mg 10 mg 100 mg 500 mg 1 g | $29.00 $82.00 $420.00 $1897.00 $3021.00 | 5 | |
Selumetinib is a selective inhibitor of MEK1/2. While its primary targets are MEK1 and MEK2, the drug could potentially exert indirect effects on MEK-5 activity due to the interconnected nature of the MAPK/ERK pathway. | ||||||
MEK 162 | 606143-89-9 | sc-488879 | 10 mg | $306.00 | ||
Binimetinib, another MEK1/2 inhibitor, can indirectly influence MEK-5 by altering signaling dynamics within the MAPK/ERK pathway, where MEK-5 also participates. | ||||||
PD 184,352 | 212631-79-3 | sc-202759 sc-202759A | 1 mg 5 mg | $40.00 $260.00 | 34 | |
PD 184,352 is a potent and selective inhibitor of MEK1/2, and it might indirectly affect MEK-5 activity through its broad action on the MEK enzymes in the MAPK/ERK pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is one of the first MEK inhibitors discovered and, while it is specific to MEK1/2, its use can potentially lead to indirect effects on MEK-5 activity, particularly in signaling cascades where MEK isoforms have overlapping or compensatory roles. | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
SL327 is known to inhibit MEK1/2 and could potentially have off-target effects on MEK-5, especially in complex signaling networks where MEK isoforms might compensate for each other's activity. | ||||||
BAY 869766 | 923032-37-5 | sc-364427 sc-364427A | 5 mg 10 mg | $245.00 $428.00 | 1 | |
BAY 869766 is a selective inhibitor of MEK1/2 and could indirectly affect MEK-5 activity through its action on these related kinases. | ||||||