9130011J15Rik Inhibitors
Chemical inhibitors of small integral membrane protein 7 (SIM7) can act through various mechanisms to impede its function within cellular processes. Amiloride, for instance, targets the Na+/H+ exchanger that SIM7 may associate with, causing a disruption in ion homeostasis and cellular pH regulation which is crucial for SIM7's activity. Genistein, a tyrosine kinase inhibitor, obstructs phosphorylation events that are likely essential for the functional activity of SIM7, by preventing activation of downstream signaling molecules that would otherwise interact with SIM7. Wortmannin and LY294002 both exert their inhibitory effects by obstructing the phosphatidylinositol 3-kinase (PI3K) pathway, which plays a pivotal role in various signaling cascades that SIM7 is a part of, thus hindering SIM7's role within these pathways.
In addition to these, the protein kinase inhibitors Go6983, GF109203X, KT5720, and Chelerythrine can suppress the activity of Protein Kinase C (PKC), and as PKC is potentially involved in the phosphorylation of proteins that interact with SIM7, this inhibition can impede SIM7's functional role in the cell. The MEK inhibitors PD98059 and U0126, and the p38 MAP kinase inhibitor SB203580, selectively target key kinases in the MAPK signaling pathway, which is often implicated in the regulation of membrane proteins similar to SIM7, leading to the suppression of SIM7's activity within the cell. Lastly, SP600125 blocks JNK activity, thereby preventing the activation of signaling networks that SIM7 may be involved in, effectively inhibiting the functional capacity of SIM7.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
Amiloride inhibits the Na+/H+ exchanger which small integral membrane protein 7 (SIM7) may associate with, leading to a decrease in cellular pH regulation and indirectly inhibiting SIM7 activity due to altered ion homeostasis. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein inhibits tyrosine kinases which could phosphorylate substrates that interact with small integral membrane protein 7, thereby inhibiting downstream signaling pathways essential for SIM7's functional activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphatidylinositol 3-kinase which is involved in signaling pathways that could interact with small integral membrane protein 7, leading to its functional inhibition. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go6983 inhibits Protein Kinase C which could be involved in phosphorylation events necessary for small integral membrane protein 7 activity, thereby inhibiting its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits PI3K, potentially disrupting cellular processes and signaling pathways that small integral membrane protein 7 is involved in, thereby inhibiting its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 selectively inhibits MEK, which could be involved in signaling pathways essential for the function of small integral membrane protein 7, resulting in its inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 inhibits MEK1/2, which are upstream regulators of pathways that small integral membrane protein 7 may be involved in, leading to the inhibition of SIM7's function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 inhibits p38 MAP kinase, potentially disrupting signaling pathways that involve small integral membrane protein 7, thus inhibiting its function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which may be part of signaling pathways that small integral membrane protein 7 functions in, leading to inhibition of SIM7. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
GF109203X inhibits Protein Kinase C, which might phosphorylate proteins that interact with small integral membrane protein 7, leading to inhibition of SIM7's activity. | ||||||