4933408B17Rik Inhibitors
Brd8dc inhibitors encompass a group of compounds that indirectly affect the function of the BRD8 domain-containing protein. These inhibitors primarily target BET (Bromodomain and Extra-Terminal motif) proteins, which are known to recognize acetylated lysine residues on histone tails, facilitating the unfolding of chromatin and subsequent transcriptional activation. By inhibiting BET proteins, these compounds can disrupt the normal interaction between Brd8dc and chromatin, thus affecting Brd8dc's role in gene expression regulation.
The inhibition mechanism is based on the competitive binding to the acetylated lysine recognition sites that are also targeted by Brd8dc. This prevents Brd8dc from associating with chromatin, leading to altered gene expression profiles within the cell. The compounds listed above, such as JQ1, OTX015, and I-BET762, bind to the bromodomains of BET proteins with high affinity, effectively displacing Brd8dc and other bromodomain-containing proteins from their chromatin binding sites.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
A BET bromodomain inhibitor that displaces Brd8dc from chromatin by competing for acetylated lysine binding sites. | ||||||
(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide | 202590-98-5 | sc-501130 | 2.5 mg | $330.00 | ||
A BET bromodomain inhibitor that may reduce the recruitment of Brd8dc to chromatin, thereby affecting its function. | ||||||
GSK 525762A | 1260907-17-2 | sc-490339 sc-490339A sc-490339B sc-490339C sc-490339D | 5 mg 10 mg 50 mg 100 mg 1 g | $300.00 $540.00 $940.00 $1680.00 $5900.00 | ||
A small molecule that inhibits BET bromodomains, potentially disrupting interactions between Brd8dc and acetylated histones. | ||||||
PFI-1 | 1403764-72-6 | sc-478504 | 5 mg | $98.00 | ||
A BET inhibitor that can modify the chromatin binding of Brd8dc, thereby affecting its role in transcription. | ||||||
CPI-0610 | 1380087-89-7 | sc-507490 | 10 mg | $495.00 | ||
A BET bromodomain and extra-terminal motif inhibitor that likely affects Brd8dc-mediated transcriptional regulation. | ||||||
RVX 208 | 1044870-39-4 | sc-472700 | 10 mg | $340.00 | ||
A BET bromodomain inhibitor that could alter the chromatin landscape and reduce Brd8dc binding to chromatin. | ||||||
MS417 | 916489-36-6 | sc-507505 | 5 mg | $228.00 | ||
A selective BET bromodomain inhibitor that might interfere with Brd8dc chromatin interaction and modulate gene expression. | ||||||