4732415M23Rik Inhibitors
Chemicals classified as indirect Spata33 inhibitors encompass a variety of compounds that interfere with spermatogenesis and testicular function. These chemicals can lead to altered expression or activity of Spata33 by affecting the cells in which Spata33 is expressed or by modulating the hormonal regulation of spermatogenesis.
For instance, compounds such as Busulfan and Cadmium exert their effects by directly damaging spermatogenic cells, which can lead to a reduction in the number of cells expressing Spata33. Endocrine disruptors like Ketoconazole and Flutamide act by altering the hormonal milieu, particularly affecting testosterone levels and androgen signaling, which are crucial for spermatogenesis and likely for the regulation of Spata33. The presence of synthetic estrogens (e.g., DES and Methoxychlor) and antiandrogens (e.g., Vinclozolin) in the system can also disturb the hormonal balance necessary for proper spermatogenesis, thereby influencing Spata33 activity. Other chemicals, including EDS, target the Leydig cells, which are responsible for testosterone production, impacting the hormonal regulation of spermatogenesis and potentially the expression of Spata33.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Busulfan | 55-98-1 | sc-204658 | 10 g | $49.00 | 3 | |
An alkylating agent that disrupts DNA in spermatogenic cells, likely affecting Spata33 by reducing the population of cells in which it is expressed. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
An antifungal that impairs steroid biosynthesis, potentially decreasing testosterone levels and thus indirectly affecting Spata33 expression. | ||||||
Flutamide | 13311-84-7 | sc-204757 sc-204757A sc-204757D sc-204757B sc-204757C | 1 g 5 g 25 g 500 g 1 kg | $47.00 $156.00 $171.00 $525.00 $941.00 | 4 | |
A nonsteroidal antiandrogen that blocks androgen receptors, possibly affecting the androgen-regulated expression of Spata33. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $85.00 | ||
Known to impair male reproductive function, which can alter Spata33 relevant pathways. | ||||||
Methoxychlor | 72-43-5 | sc-253009 | 100 mg | $36.00 | ||
An organochlorine pesticide that can mimic estrogen activity, potentially disrupting Spata33 expression. | ||||||
Vinclozolin | 50471-44-8 | sc-251425 | 250 mg | $23.00 | 1 | |
A fungicide that acts as an antiandrogen, likely altering Spata33 regulation by impacting hormone signaling. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
An industrial chemical known to have estrogenic activity, potentially affecting Spata33 expression. | ||||||