2210016F16Rik Activators
The chemical class of 8-Oxoguanine DNA Glycosylase Activators refers to a group of compounds that can indirectly influence the activity of 8-oxoguanine DNA glycosylase (OGG1). These activators are not direct modulators of OGG1 but act through enhancing cellular antioxidant capacities, DNA repair mechanisms, and overall cellular health, which are conducive to the efficient function of DNA repair enzymes like OGG1.
The first subgroup in this class includes natural antioxidants and polyphenolic compounds like Resveratrol, Curcumin, and Sulforaphane. These molecules are known to upregulate various cellular defense mechanisms against oxidative stress, a condition that often leads to the accumulation of DNA lesions like 8-oxoguanine, the primary substrate for OGG1. By enhancing the overall cellular response to oxidative stress, these compounds may indirectly support the functional efficiency of OGG1. Another significant subgroup consists of nutrients and vitamins, such as Vitamin C, N-Acetylcysteine (NAC), and Omega-3 Fatty Acids. These compounds contribute to maintaining a robust antioxidant defense system in cells. For instance, Vitamin C is a well-known antioxidant that can reduce oxidative damage to DNA, reducing the burden on OGG1. NAC, through
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a natural phenol, is known to enhance DNA repair mechanisms, potentially influencing OGG1 activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, is known for its role in activating antioxidant response elements, which may indirectly influence OGG1 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major component of green tea, has antioxidative properties and may impact DNA repair mechanisms relevant to OGG1. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties, potentially influencing OGG1 by modulating oxidative stress response pathways. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Vitamin C is an antioxidant that might enhance DNA repair processes, potentially impacting OGG1 activity. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC is known for its role in replenishing glutathione, an antioxidant that may indirectly influence OGG1 activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc plays a role in various cellular processes, including DNA repair, and might indirectly affect OGG1 function. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $146.00 $582.00 $6248.00 | 4 | |
Lycopene, a carotenoid found in tomatoes, has antioxidative properties, potentially influencing OGG1. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
Omega-3 fatty acids, found in fish oil, have been shown to influence various cellular pathways, including those related to DNA repair. | ||||||