1700028K03Rik Inhibitors
Chemical inhibitors of protein kinase 1700029I01Rik employ various strategies to impede its activity. Staurosporine, a potent inhibitor of protein kinases, can bind to the ATP-binding site of 1700029I01Rik, thus blocking its ability to transfer phosphates to substrate molecules. Similarly, Bisindolylmaleimide I targets protein kinase C (PKC), and since PKC signaling could be intertwined with the function of 1700029I01Rik, its inhibition can lead to a downstream reduction in 1700029I01Rik activity. Genistein, which inhibits tyrosine kinases, can interfere with tyrosine phosphorylation processes that are essential for the function of 1700029I01Rik. By obstructing these tyrosine kinases, Genistein can cause a reduction in the overall phosphorylation state that 1700029I01Rik might regulate.
On the other hand, inhibitors such as Wortmannin and LY294002 specifically target phosphoinositide 3-kinases (PI3K), which are upstream regulators in many kinase signaling pathways. The inhibition of PI3K leads to disruption of the PI3K/Akt pathway, which may be critical to the function of 1700029I01Rik. In a similar vein, PD98059 and U0126 act on MEK1/2, effectively blocking the MAPK/ERK pathway that could be responsible for the activation of 1700029I01Rik. SB203580 and SP600125 selectively inhibit p38 MAP Kinase and c-Jun N-terminal kinase (JNK), respectively. These kinases are central to various cellular stress responses, and their inhibition can suppress the signaling pathways that involve 1700029I01Rik. ZM-447439, an Aurora kinase inhibitor, can impede cell cycle-related events in which 1700029I01Rik may play a part. Lastly, PP2, which targets Src family kinases, can disrupt multiple signaling pathways, effectively leading to the functional inhibition of 1700029I01Rik by halting the activity of these kinases.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine inhibits a broad range of protein kinases. Since 1700029I01Rik is a kinase, staurosporine can inhibit its kinase activity directly, leading to a functional inhibition of the protein. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, wortmannin can disrupt downstream signaling that may be crucial for the kinase activity of 1700029I01Rik, resulting in its functional inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin binds to FKBP12 and the complex inhibits mTOR, a kinase involved in cell growth and proliferation. As mTOR can be part of signaling pathways that include 1700029I01Rik, rapamycin can cause functional inhibition of these pathways, thereby inhibiting the activity of 1700029I01Rik. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of PI3Ks. By inhibiting PI3K, LY294002 can disrupt the PI3K/Akt pathway which could be vital for the function of 1700029I01Rik, thus leading to its functional inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which acts upstream of ERK in the MAPK pathway. By inhibiting MEK, PD98059 can block the activation of ERK, which may be necessary for the activity of 1700029I01Rik, resulting in its functional inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 also inhibits MEK, preventing the activation of the MAPK/ERK pathway. As this pathway could be involved in the regulation or activity of 1700029I01Rik, the inhibition of this pathway by U0126 would lead to the functional inhibition of 1700029I01Rik. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP Kinase. Inhibition of p38 MAPK can disrupt cellular responses that involve 1700029I01Rik, leading to its functional inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which participates in cell stress and apoptosis pathways. By inhibiting JNK, SP600125 can disrupt pathways that involve 1700029I01Rik, leading to its functional inhibition. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor. If Aurora kinases are necessary for cell cycle progression events involving 1700029I01Rik, inhibition of these kinases by ZM-447439 would lead to the functional inhibition of 1700029I01Rik. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. By inhibiting tyrosine kinases, Genistein can disrupt signaling pathways that may involve the tyrosine kinase-like activity of 1700029I01Rik, leading to its functional inhibition. | ||||||