Cilia and flagella are hair-like structures that protrude from the surface of many eukaryotic cells. They play crucial roles in various cellular processes, including motility, sensory perception, and signal transduction. The cilia and flagella associated protein 276, often abbreviated as CFAP276, is a protein component found within these structures. Its exact role within cilia and flagella is still under investigation, but it is believed to be involved in the proper assembly and function of these organelles. Given the importance of cilia and flagella in various cellular processes, defects in their components, such as CFAP276, can lead to a range of cellular malfunctions. For instance, impaired ciliary function can result in reduced cellular motility or compromised sensory perception.
Inhibitors targeting CFAP276 are designed to modulate the function or expression of this protein. Given the intricate structure and function of cilia and flagella, inhibiting CFAP276 can have a ripple effect on the entire organelle. The exact mechanism of action of these inhibitors can vary; some might interfere with the protein's binding capabilities, preventing it from interacting with other ciliary or flagellar components. Others might inhibit the expression or synthesis of CFAP276, resulting in reduced levels of the protein within the cell. By understanding the specific interactions and roles of CFAP276 within cilia and flagella, and by examining the mechanisms through which its inhibitors operate, researchers can gain valuable insights into the dynamics of these essential cellular structures and the consequences of their disruption. This knowledge can be crucial for understanding various cellular processes and the impact of modulating CFAP276 function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine might affect the methylation status of genes like CFAP276 associated with cilia and flagella, thereby potentially altering its expression. | ||||||
Hydroxy-Dynasore | 1256493-34-1 | sc-364678 | 10 mg | $250.00 | ||
This compound inhibits dynamin, which is involved in vesicle trafficking, potentially affecting proteins involved in cilia and flagella formation like CFAP276. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
By disrupting actin filaments, cytochalasin D might interfere with cellular processes, including ciliogenesis, thus potentially affecting CFAP276 expression. | ||||||
Ciliobrevin D | 1370554-01-0 | sc-507482 | 10 mg | $413.00 | ||
Specifically targets cytoplasmic dynein, affecting ciliary function. CFAP276 expression might be affected due to its association with cilia. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3 kinase inhibitor. PI3 kinase pathways are involved in cilia formation, and its inhibition might impact CFAP276. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A binds actin monomers, affecting actin dynamics. This might indirectly impact ciliary proteins like CFAP276. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine inhibits cyclin-dependent kinases, impacting cell cycle. Given cilia's role in cell cycle, CFAP276 might be affected. | ||||||
Leflunomide | 75706-12-6 | sc-202209 sc-202209A | 10 mg 50 mg | $20.00 $81.00 | 5 | |
As an immunosuppressive drug, leflunomide might affect cellular processes and proteins associated with immune response, including those in cilia, like CFAP276. | ||||||