1700012A03Rik Inhibitors
Chemical inhibitors of 1700012A03Rik encompass a range of compounds that can interfere with the protein's activity by targeting various signaling pathways. The PI3K/AKT signaling pathway, an essential cascade affecting numerous proteins, including 1700012A03Rik, can be inhibited by substances such as Wortmannin and LY294002, which directly inhibit PI3K. This inhibition can prevent the subsequent activation of AKT, a kinase that is pivotal in regulating numerous cellular functions. Furthermore, Triciribine and ZSTK474 also target this pathway; Triciribine specifically inhibits AKT, while ZSTK474 acts as a potent PI3K inhibitor, both affecting the activity of 1700012A03Rik. Additionally, the dual-action compound PF-04691502 can block both PI3K and mTOR signaling pathways, which are integral to the regulation of 1700012A03Rik, thus offering a broader mechanism of inhibition.
In the context of mTOR pathway inhibition, Rapamycin can inhibit mTOR activity, directly affecting the regulatory mechanisms related to 1700012A03Rik. PP242 and Torin 1 extend this inhibition by targeting both mTORC1 and mTORC2 complexes that have roles in the protein's function. Inhibition of the MAPK/ERK pathway is achieved by PD98059 and U0126, which inhibit MEK1/2, thereby potentially affecting 1700012A03Rik. SB203580 and SP600125 follow a similar principle within their respective pathways; SB203580 inhibits p38 MAP kinase and SP600125 inhibits JNK activity, both pathways of which can modulate the function of 1700012A03Rik. Through these diverse mechanisms, each chemical inhibitor can alter the signaling pathways that would typically influence the activity of 1700012A03Rik, demonstrating the intricate network of internal cellular controls that can be modulated through targeted inhibition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a steroidal metabolite that inhibits phosphoinositide 3-kinases (PI3K), which can inhibit 1700012A03Rik by preventing the activation of the PI3K/AKT signaling pathway that may be crucial for the protein's function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a synthetic molecule that inhibits PI3K, leading to the inhibition of the AKT signaling pathway, which is involved in the regulation of 1700012A03Rik. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an immunosuppressive drug that inhibits mTOR, potentially inhibiting 1700012A03Rik by interfering with the mTOR signaling pathway that may regulate this protein's function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which can inhibit 1700012A03Rik by blocking the MAPK/ERK pathway that may be related to the protein's function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a pyridinyl imidazole derivative that inhibits p38 MAP kinase, potentially inhibiting 1700012A03Rik by blocking the p38 MAPK signaling pathway that could regulate this protein. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an anthrapyrazolone inhibitor that blocks the activity of c-Jun N-terminal kinase (JNK), which can inhibit 1700012A03Rik by preventing the JNK signaling pathway's influence on the protein's function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which can inhibit 1700012A03Rik by impeding the MAPK/ERK pathway's role in the regulation of the protein. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine is a nucleoside analogue that specifically inhibits AKT, which can inhibit 1700012A03Rik by obstructing the AKT signaling pathway that may be essential for the protein's activity. | ||||||
ZSTK 474 | 475110-96-4 | sc-475495 | 5 mg | $75.00 | ||
ZSTK474 is a potent PI3K inhibitor that can inhibit 1700012A03Rik by hampering the PI3K/AKT signaling pathway that may be necessary for the protein's function. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
PP242 is a selective inhibitor of mTOR kinase, and it can inhibit 1700012A03Rik by disrupting the mTOR signaling pathway that may be important for the protein's function. | ||||||