1700011E24Rik Inhibitors
Chemical inhibitors of the protein 1700011E24Rik can impede its function through various mechanisms that disrupt the signaling pathways it is involved in. Wortmannin and LY294002 are two such chemicals that target phosphoinositide 3-kinases (PI3K), an upstream regulator of 1700011E24Rik. By inhibiting PI3K, these chemicals lead to a reduction in the phosphorylation and subsequent activation of AKT, a kinase that is a central component of the signaling cascade involving 1700011E24Rik. This results in a diminished activation of 1700011E24Rik due to decreased AKT activity. Similarly, Triciribine operates by directly inhibiting AKT, thereby curtailing the signaling that is requisite for the functional activation of 1700011E24Rik. In the same vein, ZSTK474 impedes the PI3K/AKT pathway, resulting in reduced activation of 1700011E24Rik.
Parallel to these, Rapamycin and its analogs, such as PP242 and Torin 1, target the mammalian target of rapamycin (mTOR) pathway, which 1700011E24Rik is a part of. Rapamycin forms a complex with FKBP12 that binds to and inhibits mTOR, leading to a downstream reduction in protein synthesis and cell growth processes involving 1700011E24Rik. PP242 and Torin 1 are more comprehensive in their approach, inhibiting both mTORC1 and mTORC2 complexes and thus decreasing the activity of proteins in these pathways, including 1700011E24Rik. Additionally, PF-04691502 acts as a dual PI3K/mTOR inhibitor, thereby impairing the PI3K/AKT/mTOR signaling axis and reducing the activity of 1700011E24Rik. Other inhibitors like U0126 and PD98059 target the MAPK/ERK pathway, with U0126 inhibiting MEK1/2, thus preventing the activation of ERK1/2 and the subsequent signaling involving 1700011E24Rik. PD98059 also targets MEK, disrupting the MAPK pathway and therefore the role of 1700011E24Rik within it. Furthermore, SP600125 and SB203580 inhibit the JNK and p38 MAP kinase, respectively, which are critical for stress and inflammatory responses that involve 1700011E24Rik, thereby suppressing its function within these responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a PI3K inhibitor, can functionally inhibit 1700011A15Rik by obstructing the PI3K/Akt pathway, which is crucial for several cellular processes including those involving 1700011A15Rik. Inhibition of PI3K leads to a decrease in Akt phosphorylation and subsequent downstream signaling that may be vital for 1700011A15Rik's activity. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib, a tyrosine kinase inhibitor, functionally inhibits 1700011A15Rik by targeting Src family kinases. By inhibiting these kinases, Dasatinib can disrupt downstream signaling pathways where 1700011A15Rik may play a role, thereby inhibiting the protein's function. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine specifically inhibits AKT, thereby diminishing the signaling required for cell survival and proliferation, which includes 1700011E24Rik function. Reduced AKT activity directly decreases the activation of 1700011E24Rik. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAP kinase inhibitor, can functionally inhibit 1700011A15Rik by blocking p38 MAPK signaling. As p38 MAPK is involved in stress responses and cytokine production, its inhibition can disrupt processes where 1700011A15Rik is functionally involved. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059, a MEK inhibitor like U0126, can functionally inhibit 1700011A15Rik by blocking the MAPK/ERK pathway. This inhibition can lead to the functional downregulation of cellular activities where 1700011A15Rik is involved. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
PP242 is an mTOR inhibitor that directly targets both mTORC1 and mTORC2 complexes, leading to reduced activity of downstream proteins including 1700011E24Rik. By inhibiting mTOR, PP242 decreases the function of 1700011E24Rik in related signaling pathways. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin 1 is an inhibitor of mTOR known to effectively block the mTORC1 and mTORC2 signaling pathways. This leads to a reduction in the activity of downstream proteins in the pathway, including 1700011E24Rik, thereby inhibiting its function. | ||||||