17β-HSD2 Activators
17β-HSD2 activators belong to a distinct chemical class with a unique role in the regulation of steroid hormones within the human body. The term 17β-HSD2 stands for 17β-hydroxysteroid dehydrogenase type 2, which is a key enzyme involved in the interconversion of steroid hormones. Specifically, 17β-HSD2 is responsible for the conversion of biologically active steroids, such as estradiol (a potent estrogen) and testosterone (a male sex hormone), into their less active forms, estrone and androstenedione, respectively. This enzymatic activity plays a crucial role in maintaining hormone balance and preventing excessive levels of these hormones from exerting their effects.
Activators of 17β-HSD2 promote the conversion of active steroids into their less potent counterparts, thereby regulating the physiological effects of these hormones. This regulation is essential for various bodily functions, including reproductive health, as imbalances in steroid hormones can lead to conditions like hormone-sensitive cancers or disorders related to sex hormone excess or deficiency.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estradiol itself can act as an activator of 17β-HSD2, serving as a substrate and undergoing conversion to estrone (E1). | ||||||
DHEA | 53-43-0 | sc-202573 | 10 g | $109.00 | 3 | |
DHEA can activate 17β-HSD2 by serving as a precursor for testosterone and estradiol, indirectly affecting estrogen levels. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $51.00 $292.00 | 3 | |
Progesterone can stimulate 17β-HSD2 activity, likely by serving as a substrate for the enzyme, helping maintain hormonal balance. | ||||||