1600012H06Rik Inhibitors
Chemical inhibitors of the protein 1600012H06Rik provide a means to modulate its function through various signaling pathways. Staurosporine serves as a broad-spectrum kinase inhibitor that can impede the activity of 1600012H06Rik by targeting its kinase activity or the phosphorylation processes essential for its function. Similarly, Bisindolylmaleimide I focuses on the inhibition of protein kinase C (PKC), and if 1600012H06Rik is activated by PKC, this inhibitor can suppress the activation of the protein. LY294002 and Wortmannin, both phosphoinositide 3-kinases (PI3K) inhibitors, can downregulate the activity of 1600012H06Rik if it relies on PI3K signaling. These inhibitors would block the PI3K pathway, reducing the functional activity of the protein.
Furthermore, SP600125 targets the c-Jun N-terminal kinase (JNK) pathway and can thereby inhibit the function of 1600012H06Rik if it is regulated by JNK. PD98059 and U0126, which are selective inhibitors of mitogen-activated protein kinase kinase (MEK), can reduce the activity of extracellular signal-regulated kinases (ERK), and if 1600012H06Rik is part of the ERK signaling pathway, these inhibitors can suppress its function. SB203580, a selective inhibitor of p38 MAP kinase, can directly inhibit 1600012H06Rik if it is involved in the p38 MAP kinase pathway. PP2, a selective inhibitor of Src family tyrosine kinases, and Dasatinib, a broad tyrosine kinase inhibitor, can both suppress Src kinase signaling, reducing the activity of 1600012H06Rik if its function is contingent upon this pathway. Lastly, MK-2206, an allosteric inhibitor of AKT, and Rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR), can decrease the activity of 1600012H06Rik if it functions downstream or is regulated by AKT or mTOR, respectively.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine inhibits a wide range of protein kinases. If 1600012H06Rik is a kinase or is regulated by phosphorylation, staurosporine would inhibit this protein by preventing its kinase activity or the phosphorylation necessary for its activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I specifically inhibits protein kinase C (PKC). Assuming 1600012H06Rik is activated by PKC, this inhibitor would block the PKC-mediated activation of the protein, leading to functional inhibition of 1600012H06Rik. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits phosphoinositide 3-kinases (PI3K). If the activity of 1600012H06Rik is dependent on PI3K signaling, LY294002 would inhibit the PI3K pathway and subsequently inhibit the functional activity of 1600012H06Rik. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another inhibitor of PI3K. It would inhibit the functional activity of 1600012H06Rik in the same way as LY294002, provided that 1600012H06Rik is regulated by the PI3K pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits c-Jun N-terminal kinase (JNK). Should 1600012H06Rik be a substrate of JNK or its activity be JNK-dependent, SP600125 would inhibit the JNK pathway, thereby inhibiting the function of 1600012H06Rik. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is upstream of extracellular signal-regulated kinases (ERK). Inhibition of MEK by PD98059 would lead to reduced ERK activity, and if 1600012H06Rik requires ERK signaling for its function, this would result in inhibition of 1600012H06Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 also inhibits MEK. By inhibiting MEK and consequently ERK signaling, U0126 would inhibit the protein kinase activity of 1600012H06Rik if it is part of the ERK pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. If 1600012H06Rik is involved in the p38 MAP kinase pathway, inhibition by SB203580 would directly inhibit the function of 1600012H06Rik. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. If 1600012H06Rik's activity is contingent upon Src kinase signaling, PP2 would inhibit this signaling and thus the function of 1600012H06Rik. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
MK-2206 is an allosteric inhibitor of AKT. By inhibiting AKT, MK-2206 would inhibit the function of 1600012H06Rik if 1600012H06Rik's function is AKT-dependent. | ||||||