Date published: 2025-9-8

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TIMP-3 抗体 (B-2): sc-373839

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说明书
  • TIMP-3 抗体 B-2 是小鼠单克隆 IgG3 κ,TIMP-3抗体, 在15篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的TIMP-3的C-terminus的氨基酸181-210之间
  • 推荐用于 mouse, rat 和 human 来源的TIMP-3 WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: 和 equine, canine, bovine and porcine
  • 关于如何获取TIMP-3 (B-2): sc-373839免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成TIMP-3 抗体 (B-2)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

TIMP-3抗体(B-2)是一种IgG3 κ小鼠单克隆TIMP-3抗体(也称为TIMP3抗体、金属蛋白酶3的组织抑制剂抗体或MIG-5抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人源的TIMP-3蛋白。TIMP-3抗体(B-2)为非偶联的抗TIMP-3抗体。TIMP-1、TIMP-2、TIMP-3和TIMP-4(分别对应金属蛋白酶1、2、3和4的组织抑制剂)与金属蛋白酶如胶原酶、明胶酶和基质溶素复合,导致金属蛋白酶的不可逆失活。已发现TIMP-1与EPA(促红细胞生成活性)相同。甲状旁腺激素已被证明是成骨细胞中TIMP-2的调节剂。TIMP-3可能参与调节滋养层对子宫的侵袭以及上皮细胞折叠过程中细胞外基质的重塑,以及上皮管的形成、分支和扩张。TIMP-4在心脏中的表达量最高,在肝、脑、肺、胸腺和脾脏中的表达量较低。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TIMP-3 抗体 (B-2) 参考文献:

  1. 人成纤维细胞胶原酶抑制剂的一级结构和 cDNA 克隆。  |  Carmichael, DF., et al. 1986. Proc Natl Acad Sci U S A. 83: 2407-11. PMID: 3010309
  2. 将 TIMP-3 改造成 LAP 融合蛋白,用于靶向炎症部位。  |  Alberts, BM., et al. 2019. J Cell Mol Med. 23: 1617-1621. PMID: 30450736
  3. 作为癌症治疗靶点的 TIMP-3。  |  Su, CW., et al. 2019. Ther Adv Med Oncol. 11: 1758835919864247. PMID: 31360238
  4. TIMP-3的多种作用:衰老视网膜和大脑退行性疾病的见解。  |  Dewing, JM., et al. 2019. Cells. 9: PMID: 31877820
  5. 组织金属蛋白酶 3 抑制剂 (TIMP3) 的生物学特性及其对心血管病学的治疗意义。  |  Fan, D. and Kassiri, Z. 2020. Front Physiol. 11: 661. PMID: 32612540
  6. 人类组织金属蛋白酶抑制剂的序列及其与促红细胞生成素活性的一致性。  |  Docherty, AJ., et al. Nature. 318: 66-9. PMID: 3903517
  7. 组织金属蛋白酶抑制剂(TIMP)-3 的基因结构及其抑制活性定义了独特的 TIMP 基因家族。  |  Apte, SS., et al. 1995. J Biol Chem. 270: 14313-8. PMID: 7782289
  8. 编码一种新型小鼠金属蛋白酶组织抑制剂(TIMP)(TIMP-3)的基因在发育中的小鼠上皮, 软骨和肌肉中表达,该基因位于小鼠第 10 号染色体上。  |  Apte, SS., et al. 1994. Dev Dyn. 200: 177-97. PMID: 7949367
  9. 克隆编码组织金属蛋白酶抑制剂家族新成员人类 TIMP-3 的 cDNA。  |  Silbiger, SM., et al. 1994. Gene. 141: 293-7. PMID: 8163205
  10. 大鼠组织金属蛋白酶抑制剂-2在成骨细胞中的克隆和调控。  |  Cook, TF., et al. 1994. Arch Biochem Biophys. 311: 313-20. PMID: 8203893
  11. 人组织金属蛋白酶抑制剂 4 的分子克隆和特征描述。  |  Greene, J., et al. 1996. J Biol Chem. 271: 30375-80. PMID: 8939999
  12. 组织金属蛋白酶抑制剂:结构, 调节和生物功能。  |  Gomez, DE., et al. 1997. Eur J Cell Biol. 74: 111-22. PMID: 9352216

订购信息

产品名称产品编号规格价格数量收藏夹

TIMP-3 抗体 (B-2)

sc-373839
200 µg/ml
$316.00

TIMP-3 (B-2) 中和勝肽

sc-373839 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-373839 P appropriate for?

Asked by: DefinitelyNotMatt
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from Endogenous TIMP3 in HEK293 lysatesDetects a band of the right size for TIMP3, in HEK293 lysates.
Date published: 2018-02-21
Rated 4 out of 5 by from Good productI bought this antibody for human TM cells staining. 1 in 100 dilution was used in my case.
Date published: 2017-09-11
Rated 5 out of 5 by from Absolutely worksThis antibody Absolutely works, so I highly recommend
Date published: 2017-07-04
Rated 5 out of 5 by from This antibody is good.I used for western blot. Strong signal and good band with no noise.
Date published: 2017-06-02
Rated 5 out of 5 by from Very good band.You will enjoy working with this antibody. It gave strong signal and band in brain cell lysates.
Date published: 2017-05-30
Rated 5 out of 5 by from fine bandsworked really great. Got fine bands in western analysis with clear background.
Date published: 2017-03-07
Rated 1 out of 5 by from Not the bestIn a side-by-side comparison of TIMP-3 antibodies from Santa Cruz and another leading supplier, the Santa Cruz one came up short: no bands!
Date published: 2017-02-07
Rated 5 out of 5 by from Good for WBThis antibody shows strong detection of recombinant TIMP-3 in Western Blot with no observed background.
Date published: 2017-02-02
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TIMP-3 抗体 (B-2) is rated 4.3 out of 5 by 10.
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