SREBP-1 Antibody (3F335): sc-73058
- SREBP-1 Antibody (3F335) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 301-407 of SREBP-1 of human origin
- recommended for detection of SREBP-1 of mouse, rat, human and hamster origin by WB and IP
- See SREBP-1 (A-4): sc-365513 for SREBP-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for SREBP-1 Antibody (3F335) for WB applications. These reagents are now offered in bundles with SREBP-1 Antibody (3F335) (see ordering information below).
SREBP-1 Antibody (3F335) is a mouse monoclonal IgG1 antibody that detects SREBP-1 in mouse, rat, human, and hamster samples through applications such as western blotting (WB) and immunoprecipitation (IP). SREBP-1, also known as adipocyte determination and differentiation factor 1, plays a crucial role in lipid metabolism by regulating the expression of genes involved in cholesterol and fatty acid synthesis. SREBP-1 is primarily located in the endoplasmic reticulum and the nuclear envelope, where SREBP-1 exists as a precursor form. Upon sterol depletion, SREBP-1 undergoes proteolytic cleavage, releasing a soluble fragment that translocates to the nucleus to activate transcription of target genes, thereby enhancing the uptake of low-density lipoprotein (LDL) and promoting lipid biosynthesis. The regulation of SREBP-1 is vital for maintaining cellular lipid homeostasis, as excessive cholesterol accumulation can lead to various metabolic disorders. Anti-SREBP-1 antibody (3F335) is an essential tool for researchers studying lipid metabolism and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SREBP-1 Antibody (3F335) References:
- Connecting mTORC1 signaling to SREBP-1 activation. | Bakan, I. and Laplante, M. 2012. Curr Opin Lipidol. 23: 226-234. PMID: 22449814
- SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells. | Chen, G., et al. 2014. J Mol Cell Biol. 6: 516-30. PMID: 25348957
- SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis. | Wang, TN., et al. 2015. J Am Soc Nephrol. 26: 1839-54. PMID: 25398788
- Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation. | Smulan, LJ., et al. 2016. Cell Rep. 16: 9-18. PMID: 27320911
- SREBP-1 is an independent prognostic marker and promotes invasion and migration in breast cancer. | Bao, J., et al. 2016. Oncol Lett. 12: 2409-2416. PMID: 27703522
- Impact of silencing hepatic SREBP-1 on insulin signaling. | Jideonwo, V., et al. 2018. PLoS One. 13: e0196704. PMID: 29723221
- UBC12-mediated SREBP-1 neddylation worsens metastatic tumor prognosis. | Heo, MJ., et al. 2020. Int J Cancer. 147: 2550-2563. PMID: 32449166
- GDNF regulates lipid metabolism and glioma growth through RET/ERK/HIF‑1/SREBP‑1. | Yu, Z., et al. 2022. Int J Oncol. 61: PMID: 35894143
- circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells. | Li, Q., et al. 2022. Cell Rep. 41: 111707. PMID: 36417875
- The Effects of Synthetic SREBP-1 and PPAR-γ Decoy Oligodeoxynucleotide on Acne-like Disease In Vivo and In Vitro via Lipogenic Regulation. | Gu, H., et al. 2022. Biomolecules. 12: PMID: 36551286
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SREBP-1 Antibody (3F335) | sc-73058 | 200 µg/ml | $322.00 | |||
SREBP-1 Antibody (3F335): m-IgG Fc BP-HRP Bundle | sc-539446 | 200 µg Ab; 10 µg BP | $361.00 | |||
SREBP-1 Antibody (3F335): m-IgG1 BP-HRP Bundle | sc-541493 | 200 µg Ab; 20 µg BP | $361.00 |