Date published: 2025-9-7

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SMS2 抗体 (7D10): sc-293384

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说明书
  • SMS2 抗体 7D10 是小鼠单克隆 IgG2a κ,SMS2抗体, 在3篇文献中引用,规格为100 µg/ml
  • 免疫human物种的SMS2的氨基酸2-80
  • 推荐用于 human 来源的SMS2 WB, IP 和 ELISA检测
  • 关于如何获取SMS2 (7D10): sc-293384免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRPm-IgGκ BP-HRP是SMS2 Antibody (7D10) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与SMS2 Antibody (7D10) 打包提供(请参阅下面的订购信息)。

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関連項目

SMS2抗体(7D10)是一种小鼠单克隆IgG2a kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)和酶联免疫吸附测定(ELISA)检测人类来源的SMS2蛋白。抗SMS2抗体(7D10)以非结合形式提供。SMS(鞘氨醇合成酶)家族包括SMS1和SMS2,在脂质代谢中发挥着关键作用,尤其是鞘氨醇合成,这是细胞膜的重要组成部分。SMS2主要位于质膜上,在那里SMS2作为双向脂质胆碱磷酸转移酶,根据底物浓度将磷脂酰胆碱和神经酰胺转化为鞘氨醇和二酰基甘油,反之亦然。这种调节对于维持细胞内稳态和信号传导至关重要,因为鞘磷脂参与细胞凋亡和细胞存活等多种细胞过程。SMS2的活性受多种因素影响,包括特异性抑制剂,如三环癸烷-9-基-黄原酸酯(D609),该抑制剂已被证明可抑制SMS活性并促进肿瘤细胞的细胞毒性。SMS2在肝脏、肌肉、心脏、大脑、胃和肾脏等多个组织中均有表达,这表明SMS2在多种生理功能中发挥着重要作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

SMS2 抗体 (7D10) 参考文献:

  1. 鉴定动物鞘磷脂合成酶家族。  |  Huitema, K., et al. 2004. EMBO J. 23: 33-44. PMID: 14685263
  2. 鞘磷脂合成酶是 D609 诱导 U937 人单核细胞白血病细胞凋亡的潜在靶点。  |  Meng, A., et al. 2004. Exp Cell Res. 292: 385-92. PMID: 14697345
  3. 克隆表达能恢复鞘磷脂合成酶缺陷淋巴细胞中鞘磷脂合成和细胞生长的人类 cDNA。  |  Yamaoka, S., et al. 2004. J Biol Chem. 279: 18688-93. PMID: 14976195
  4. 小鼠的鞘磷脂合成酶 1(SMS1)基因是交替剪接的,可产生多种转录本和蛋白质。  |  Yang, Z., et al. 2005. Gene. 363: 123-32. PMID: 16226406
  5. 鞘磷脂合成酶是 SV40 转化过程中细胞内神经酰胺和二酰甘油水平的潜在调节器。鞘磷脂合成酶是否解释了假定的磷脂酰胆碱特异性磷脂酶 C?  |  Luberto, C. and Hannun, YA. 1998. J Biol Chem. 273: 14550-9. PMID: 9603970

订购信息

产品名称产品编号规格价格数量收藏夹

SMS2 抗体 (7D10)

sc-293384
100 µg/ml
$316.00

SMS2 (7D10): m-IgG Fc BP-HRP 套装

sc-537740
100 µg Ab; 10 µg BP
$354.00

SMS2 (7D10): m-IgGκ BP-HRP 套装

sc-535106
100 µg Ab; 40 µg BP
$354.00

SMS2 (7D10): m-IgG2a BP-HRP 套装

sc-548104
100 µg Ab; 10 µg BP
$354.00

would this be suitable for IHC-P for both mouse and human tissue? and is it possible to receive this without the gelatin (just PBS)? 

Asked by: Wagma
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-22

For Western Blot, is it recommended to use denatured or non-denatured conditions with SMS2 (7D10): sc-293384 antibody?

Asked by: Cweed
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by from Good for Western BlotAntibody works for Western blot with HeLa-mCAT#8 and JAR4-derived cell line SMS1KO22/SMS2 (stably expressing SMS2) cell extracts in published research. -SCBT QC
Date published: 2023-09-14
Rated 5 out of 5 by from On SMS2 AbThis antibody worked great for immunoblotting of HeLa total cell lysates.
Date published: 2020-07-02
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SMS2 抗体 (7D10) is rated 5.0 out of 5 by 2.
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