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SH2-B α/β/γ/δ 抗体 (C-11): sc-514142

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说明书
  • SH2-B α/β/γ/δ抗体(C-11)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于rat物种的SH2-B ∫的N-terminus的氨基酸2-24之间
  • 推荐用于 mouse, rat 和 human 来源的SH2-B α, SH2-B β, SH2-B γ and SH2-B δ WB, IP, IF 和 ELISA检测
  • 关于如何获取SH2-B α/β/γ/δ (C-11): sc-514142免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP是SH2-B α/β/γ/δ Antibody (C-11) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与SH2-B α/β/γ/δ Antibody (C-11) 搭配使用(请参阅下面的订购信息)。有关其它 m-IgGκ BP 结合物,请参阅我们完整的小鼠 IgG 结合蛋白列表。

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    SH2-B α/β/γ/δ 抗体(C-11)是一种IgG1 κ小鼠单克隆SH2-B α/β/γ/δ抗体,可通过WB、IP、IF和ELISA方法检测到来自小鼠、大鼠和人类的SH2-B α、SH2-B β、SH2-B γ和SH2-B δ。SH2-B α/β/γ/δ 抗体(C-11)可用作非偶联形式的抗SH2-B α/β/γ/δ抗体。SH2-B,也被称为SH2B1或PSM,是一种由756个氨基酸组成的蛋白质,是信号网络的一个组成部分,参与细胞形态和运动的调节。SH2-B与APS(含有PH和SH2结构域的适配分子)家族的适配蛋白相关,这类蛋白的特征是含有一个血小板同源(PH)结构域、一个SH2结构域和一个酪氨酸磷酸化位点。SH2-B通过选择性剪接产生三种不同的异构体,即SH2-B α、β和γ,它们具有相同的N端序列,包括PH结构域、SH2结构域和多个富含脯氨酸的模体。由于含有一个PH结构域和一个SH2结构域,SH2-B在细胞核和细胞质之间穿梭。SH2-B广泛表达,在骨骼肌和卵巢中的表达水平最高。SH2-B在酪氨酸残基上磷酸化以响应受体激酶的刺激。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    SH2-B α/β/γ/δ 抗体 (C-11) 参考文献:

    1. 神经生长因子诱导的神经元分化需要 SH2-B。  |  Rui, L., et al. 1999. J Biol Chem. 274: 10590-4. PMID: 10187854
    2. 鉴定 SH2-bbeta 是酪氨酸激酶 Janus 激酶 2 的强效细胞质激活剂。  |  Rui, L. and Carter-Su, C. 1999. Proc Natl Acad Sci U S A. 96: 7172-7. PMID: 10377387
    3. APS是一种具有PH和SH2结构域的适配蛋白,是胰岛素受体激酶的底物。  |  Ahmed, Z., et al. 1999. Biochem J. 341 (Pt 3): 665-8. PMID: 10417330
    4. SH2-B是一种膜相关适配器,在神经生长因子的作用下,会被MEK/ERK级联内的激酶磷酸化多个丝氨酸/苏氨酸。  |  Rui, L., et al. 1999. J Biol Chem. 274: 26485-92. PMID: 10473609
    5. SH2-beta的SH2结构域和N-末端区域与JAK2的不同结合和调控。  |  Rui, L., et al. 2000. Mol Cell Biol. 20: 3168-77. PMID: 10757801
    6. 与生长激素受体偶联所需的 JAK2 酪氨酸激酶区域。  |  Frank, SJ., et al. 1995. J Biol Chem. 270: 14776-85. PMID: 7540178
    7. 确定 SH2-Bbeta 是参与生长激素信号传导的酪氨酸激酶 JAK2 的底物。  |  Rui, L., et al. 1997. Mol Cell Biol. 17: 6633-44. PMID: 9343427
    8. 血小板衍生生长因子(PDGF)会刺激 SH2-Bbeta 与 PDGF 受体结合并使 SH2-Bbeta 磷酸化。  |  Rui, L. and Carter-Su, C. 1998. J Biol Chem. 273: 21239-45. PMID: 9694882

    订购信息

    产品名称产品编号规格价格数量收藏夹

    SH2-B α/β/γ/δ 抗体 (C-11)

    sc-514142
    200 µg/ml
    $316.00

    SH2-B α/β/γ/δ (C-11): m-IgGκ BP-HRP 套装

    sc-524620
    200 µg Ab, 40 µg BP
    $354.00

    SH2-B α/β/γ/δ (C-11) 中和勝肽

    sc-514142 P
    100 µg/0.5 ml
    $68.00

    What application is the blocking peptide sc-514142 P appropriate for?

    Asked by: DefinitelyNotMatt
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-28
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    Rated 1 out of 5 by from Immunoblot of the endogenous SH2B1 in PC12 cellsAnti-SH2B1 (C11) against aa 2-24 of rat SH2B1 (sc. 514142) PC12 cells stably expressing GFP tag (only endogenous SH2B1 present). Treated ± NGF (100 ng/ml), cells lysed in RIPA buffer (1% Triton X100). Load 40 ul on minigel. Immunoblot Block with 3% BSA in TBS-1% tween Blot anti-SH2B1 (C11) (1/250 dilution) 2o antibody mIGGkBP-HRP (sc) (1/1000) No SH2B1 signal detected When PC12 cells stably expressing GFP-SH2B1 beta were used, no band was detected at ~125 kDa. No difference was detected between the GFP-SH2B1 beta and GFP-alone lanes.
    Date published: 2018-08-23
    Rated 5 out of 5 by from Great Western blot data of SH2Great Western blot data of SH2-B / / / expression in SJRH30 whole cell lysate. -SCBT QC
    Date published: 2014-04-08
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    SH2-B α/β/γ/δ 抗体 (C-11) is rated 3.0 out of 5 by 2.
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