SH2-B Inhibitors
SH2-B inhibitors represent a class of small molecules designed to target and modulate the activity of the SH2-B family of adapter proteins. SH2-B proteins, also known as SH2B1, SH2B2, and SH2B3, play crucial roles in mediating cellular signaling events by interacting with various receptor tyrosine kinases and cytoplasmic signaling proteins. These adapter proteins are characterized by the presence of Src homology 2 (SH2) and pleckstrin homology (PH) domains, which allow them to participate in protein-protein interactions and facilitate signal transduction. SH2-B inhibitors are specifically designed to interfere with the functioning of SH2-B proteins, affecting downstream signaling pathways.
At the molecular level, SH2-B inhibitors typically target the SH2 domain of SH2-B proteins, as this domain plays a central role in their interactions with phosphotyrosine residues on activated receptor tyrosine kinases and downstream signaling proteins. By binding to the SH2 domain, these inhibitors disrupt the formation of critical protein complexes, preventing the recruitment of downstream effectors and impairing signal transduction cascades. This interference leads to a disruption of cellular responses that rely on SH2-B-mediated signaling events, such as those involved in growth factor signaling, insulin signaling, and cytokine signaling. While the specific mechanisms of action may vary among individual SH2-B inhibitors, their common goal is to modulate the function of SH2-B proteins and, consequently, influence various cellular processes and pathways. Researchers have explored these inhibitors in the context of understanding cellular signaling mechanisms and have demonstrated their utility as valuable tools for elucidating the intricacies of signal transduction pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol inhibits SH2-B by interfering with its phosphorylation, thereby disrupting its interaction with downstream signaling proteins like insulin receptor substrate (IRS) and insulin-like growth factor 1 receptor (IGF-1R). This inhibition leads to reduced insulin signaling and downstream metabolic effects. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent SH2-B inhibitor that acts by targeting the phosphoinositide 3-kinase (PI3K) pathway. It irreversibly inhibits PI3K, a protein upstream of SH2-B in insulin signaling, preventing SH2-B activation and subsequent downstream signaling. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 (AG 490) is a Janus kinase (JAK) inhibitor that indirectly affects SH2-B by disrupting cytokine signaling. By inhibiting JAK activity, it interferes with downstream signaling pathways, including those involving SH2-B, leading to impaired cellular responses. | ||||||
Syk Inhibitor IV, BAY 61-3606 HCl | 732983-37-8 | sc-202351 | 2 mg | $327.00 | 25 | |
BAY 61-3606 is a selective Syk kinase inhibitor that interferes with the SH2-B pathway by blocking Syk-mediated signaling. By inhibiting Syk, it disrupts downstream events and impairs cellular responses involving SH2-B. | ||||||
AG 825 | 149092-50-2 | sc-202045 sc-202045A sc-202045B sc-202045C | 2 mg 5 mg 10 mg 100 mg | $47.00 $94.00 $183.00 $1769.00 | ||
AG-825 inhibits SH2-B indirectly by targeting the epidermal growth factor receptor (EGFR) pathway. It prevents EGFR activation, which affects downstream signaling cascades, including those involving SH2-B, impacting cellular responses. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a selective Src kinase inhibitor that indirectly affects SH2-B by disrupting Src-mediated signaling. By inhibiting Src, it interferes with downstream events and impairs cellular responses involving SH2-B. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib inhibits SH2-B by targeting multiple tyrosine kinases, including Src family kinases. This broad inhibition affects downstream signaling pathways involving SH2-B and impacts cellular responses to various growth factors. | ||||||
Janex-1 | 202475-60-3 | sc-205354 sc-205354A | 1 mg 5 mg | $36.00 $153.00 | 1 | |
Janex-1 (WHI-P131) is a Janus kinase 3 (JAK3) inhibitor that indirectly affects SH2-B by blocking JAK3-mediated signaling. By inhibiting JAK3, it interferes with downstream events and impairs cellular responses involving SH2-B. | ||||||