Date published: 2025-9-7
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SENP6 Antibody (79-M) - Western Blotting - Image 33958
SENP6 抗体 (79-M): sc-100585. IMR-32 全细胞裂解液中 SENP6 表达的 Western 印迹分析.
SENP6 Antibody (79-M) - Western Blotting - Image 33958
SENP6 抗体 (79-M): sc-100585. IMR-32 全细胞裂解液中 SENP6 表达的 Western 印迹分析.
SENP6 Antibody (79-M) - Immunohistochemistry - Image 36082
SENP6 抗体 (79-M): sc-100585. 福尔马林固定, 石蜡包埋的人胃组织的免疫过氧化物酶染色, 显示细胞核和细胞质定位.
SENP6 Antibody (79-M) - Western Blotting - Image 412725
SENP6抗体（79-M）：sc-100585。SENP6在未经处理的HeLa（A）、化学处理的HeLa（B）和K-562（C）全细胞裂解液中的表达的Western印迹分析。检测试剂：m-IgG2a BP-HRP：sc-542731。β-Actin (C4)：sc-47778用作加载对照。检测试剂：m-IgG Fc BP-HRP：sc-525409。
SENP6 抗体 (79-M): sc-100585. IMR-32 全细胞裂解液中 SENP6 表达的 Western 印迹分析.

SENP6 抗体 (79-M): sc-100585

4.4(5)
寫評論提問

说明书
  • SENP6 抗体 79-M 是小鼠单克隆 IgG2a κ，SENP6抗体, 在7篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组SENP6
  • 推荐用于 human 来源的SENP6 WB, IP, IF, IHC(P) 和 ELISA检测
  • 关于如何获取SENP6 (79-M): sc-100585的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG2a BP-HRP 和 m-IgGκ BP-HRP 是 SENP6 抗体 (79-M) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与SENP6 抗体 (79-M) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 SENP 抗体 包括 SENP1, SENP3, SENP5, SENP6, SENP7和SENP8

SENP6抗体（79-M）是一种IgG2a κ小鼠单克隆SENP6抗体，可通过WB、IP、IF、IHC（P）和ELISA检测人源SENP6蛋白。SENP6抗体（79-M）可作为非偶联抗SENP6抗体使用。SUMO（small ubiquitin-related modifier，小泛素相关修饰物）是泛素样蛋白家族的一员，可调节多种靶蛋白的多种细胞功能，包括转录、DNA修复、核质转运和染色体分离。SUMO前体蛋白在成熟过程中会由SUMO特异性蛋白酶在"GG"区域之后进行残基裂解。前体的这种裂解是随后进行SUMO化的先决条件。sentrin特异性（或SUMO特异性）蛋白酶（SENP）蛋白属于肽酶C48家族，包括SENP1-3和SENP5-8。SENP1、SENP2和SENP3可降解UBL1和SMT3H2结合物，随后从SUMO化底物中释放单体。HIPK2是SENP1的一个去SUMO化靶标，可在细胞质和细胞核之间穿梭。突变分析表明，SENP1在极端羧基末端区域含有核输出序列（NES），并且SENP1以NES依赖的方式输出到细胞质。SENP2已被证实为CTNNB1水平的下调因子，因此可能是Wnt通路的调节因子。SUMO蛋白酶SENP3可逆转MEF2的SUMO化，以增强其转录和成肌活性。SENP5定位于核仁，并优先处理SUMO-3。它被认为在有丝分裂和/或细胞质分裂中发挥作用。SENP6定位于细胞质并释放SUMO-1。SENP6在生殖器官中的表达较高，表明其可能介导与生殖相关的过程。SENP8参与sentrins的释放。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

SENP6 抗体 (79-M) 参考文献:

  1. 一种新型中性蛋白特异性蛋白酶对中性蛋白的不同调控。  |  Gong, L., et al. 2000. J Biol Chem. 275: 3355-9. PMID: 10652325
  2. 一种在生殖器官中高度表达的新型 SUMO-1 特异性蛋白酶 SUSP1。  |  Kim, KI., et al. 2000. J Biol Chem. 275: 14102-6. PMID: 10799485
  3. SENP1 通过对组蛋白去乙酰化酶 1 进行脱umoylation 来增强雄激素受体依赖性转录。  |  Cheng, J., et al. 2004. Mol Cell Biol. 24: 6021-8. PMID: 15199155
  4. 通过分析人类 Senp2 和 Senp2-SUMO 复合物为 SUMO 蛋白酶特异性提供依据。  |  Reverter, D. and Lima, CD. 2004. Structure. 12: 1519-31. PMID: 15296745
  5. 绘制在 SUMO 特异性蛋白酶 SENP1 的不同成熟过程中必不可少的 SUMO 前体残基图。  |  Xu, Z. and Au, SW. 2005. Biochem J. 386: 325-30. PMID: 15487983
  6. 通过SUMO特异性蛋白酶SENP1的胞质核穿梭作用，对同源模域相互作用蛋白激酶2（HIPK2）进行脱SUMO酰化。  |  Kim, YH., et al. 2005. FEBS Lett. 579: 6272-8. PMID: 16253240
  7. SENP1-SUMO-2 复合物的结构表明，在处理过程中，SUMO 对映体之间的区别具有结构基础。  |  Shen, LN., et al. 2006. Biochem J. 397: 279-88. PMID: 16553580
  8. 偏好 SUMO-2 或 SUMO-3 的细胞核 SUMO 特异性蛋白酶家族的特征。  |  Gong, L. and Yeh, ET. 2006. J Biol Chem. 281: 15869-77. PMID: 16608850
  9. 细胞分裂需要SUMO特异性蛋白酶SENP5。  |  Di Bacco, A., et al. 2006. Mol Cell Biol. 26: 4489-98. PMID: 16738315

订购信息

产品名称产品编号规格价格数量收藏夹

SENP6 抗体 (79-M)

sc-100585
100 µg/ml
$333.00

SENP6 (79-M): m-IgGκ BP-HRP 套装

sc-534509
100 µg Ab; 40 µg BP
$354.00

SENP6 (79-M): m-IgG2a BP-HRP 套装

sc-546191
100 µg Ab; 10 µg BP
$354.00

What concentration of antibody and concentration of cell extract did you use for the Western Blot in the sample image?

Asked by: gradstudent1
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-11-01

Hello, I am a PhD student working at the DKFZ in Heidelberg, Germany and am interested in the SENP6 (79-M): sc-100585 antibody. I would like to test it for immunofluorescence studies before purchasing. Could I please receive a free sample?

Asked by: Anonymous
Thank you for your question. Please contact our Technical Service Department for more information on how to receive a free 10 ug sample of this monoclonal antibody.
Answered by: Tech Service
Date published: 2020-01-08

Can sc-100585: SENP6 (79-M) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: DefinitelyNotMatt
Thank you for your question. Yes, sc-100585: SENP6 (79-M) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24

Hi, Would it be possible to get a free trial sample size of this Antibody? I'd like to ensure the antibody works for platelet lysate before purchasing a full size product. Many thanks

Asked by: SarahR
Thank you for your question. We do not normally offer samples sizes of this SENP6 antibody. We have not tested the antibody on human platelet lysate and do not have any data regarding SENP6 expression in this sample. Please contact our Technical Service Department to inquire about the possibility of receiving a free sample size of this antibody. Please call our European Support office toll-free at 00800 4573 8000, email europe@scbt.com, or contact us by live chat.
Answered by: Technical Support
Date published: 2017-01-27
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Rated 5 out of 5 by from Good for Western BlotThis antibody has been used for western blot in published research. -SCBT QC
Date published: 2023-09-14
Rated 4 out of 5 by from Good antibody for WBSpecific antibody for western blot using MCF7 whole cell extract.
Date published: 2018-01-27
Rated 5 out of 5 by from Strong bands in western blot analysisThe antibody was perfect. There is no background detected, and detected very strong signal.
Date published: 2017-09-22
Rated 4 out of 5 by from Good immunoperoxidase nuclear and cytoplasmicGood immunoperoxidase nuclear and cytoplasmic staining in formalin-fixed, paraffin-embedded human stomach tissue. -SCBT QC
Date published: 2015-04-03
Rated 4 out of 5 by from Strong band in WB in IMRStrong band in WB in IMR-32 whole cell lysate. -SCBT QC
Date published: 2015-03-31
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SENP6 抗体 (79-M) is rated 4.4 out of 5 by 5.
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