PYK2 Antibody (5E2D5): sc-130077

PYK2 Antibody (5E2D5) is a mouse monoclonal IgG2a antibody that detects PYK2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). PYK2, also known as proline-rich tyrosine kinase 2, plays a crucial role in cellular signaling, particularly in the central nervous system, where PYK2 is highly expressed. PYK2 is involved in the modulation of ion channel function and the activation of the mitogen-activated protein kinase (MAPK) signaling pathway, which is essential for various cellular processes, including growth, differentiation, and response to stress. The activation of PYK2 occurs rapidly in response to stimuli that elevate intracellular calcium levels, as well as through the action of phorbol esters that activate protein kinase C (PKC) family members. Notably, PYK2 undergoes significant post-translational modifications, including phosphorylation on tyrosine residues, which are critical for function and regulation. The unique structural organization of PYK2, with a high degree of sequence identity to focal adhesion kinase (FAK), underscores PYK2′s importance in cellular signaling networks and highlights PYK2′s potential as a therapeutic target in various diseases. Anti-PYK2 antibody (5E2D5) is an invaluable tool for researchers investigating the intricate roles of this kinase in human health and disease.

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PYK2 Antibody (5E2D5) References:

1. Pyk2 is essential for astrocytes mobility following brain lesion.  |  Giralt, A., et al. 2016. Glia. 64: 620-34. PMID: 26663135
2. PYK2 mediates BzATP-induced extracellular matrix proteins synthesis.  |  Torigoe, G., et al. 2017. Biochem Biophys Res Commun. 494: 663-667. PMID: 29061307
3. Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development.  |  Naser, R., et al. 2018. Cancers (Basel). 10: PMID: 29891810
4. Pyk2 promotes tumor progression in renal cell carcinoma.  |  Zhao, T., et al. 2018. Oncol Lett. 16: 5953-5959. PMID: 30344745
5. The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC.  |  Khera, L., et al. 2021. Life Sci Alliance. 4: PMID: 33785524
6. Pyk2 regulates cell-edge protrusion dynamics by interacting with Crk.  |  Lukic, N., et al. 2021. Mol Biol Cell. 32: ar17. PMID: 34432482
7. PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas.  |  Shen, J., et al. 2021. Cancer Biol Med. 19: 1211-23. PMID: 34570440
8. Role of proline-rich tyrosine kinase 2 (Pyk2) in the pathogenesis of Alzheimer's disease.  |  Kumar, R., et al. 2022. Eur J Neurosci. 56: 5442-5452. PMID: 34905657
9. Inhibition of Pyk2 Improves Cx43 Intercalated Disc Localization, Infarct Size, and Cardiac Function in Rats With Heart Failure.  |  Zheng, L., et al. 2023. Circ Heart Fail. 16: e010294. PMID: 37465947
10. Enhanced phagocytosis associated with multinucleated microglia via Pyk2 inhibition in an acute β-amyloid infusion model.  |  Lee, JW., et al. 2024. J Neuroinflammation. 21: 196. PMID: 39107821

The preferred p-PYK2 antibody is p-PYK2 Antibody (13.Tyr 402): sc-293142.