PTPζ Antibody (122.2): sc-33664

PTPζ Antibody (122.2) is a mouse monoclonal IgM antibody that detects PTPζ protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-PTPζ antibody (122.2) is available as the non-conjugated format. PTPζ protein, a member of the protein tyrosine phosphatase family, plays a crucial role in cellular signaling pathways, particularly in the regulation of cell growth, differentiation, and survival. PTPζ (122.2) antibody is vital for studying functions in the nervous system, where PTPζ is involved in the modulation of synaptic plasticity and neuronal signaling. PTPζ protein interacts with various proteins, including the chondroitin sulfate proteoglycan phosphacan, which is generated through alternative splicing and is essential for neural development and regeneration. PTPζ presence in the cell membrane and ability to dephosphorylate tyrosine residues makes PTPζ a key player in the regulation of receptor tyrosine kinases, influencing processes such as insulin signaling and cell adhesion. Understanding PTPζ dynamics and interactions can provide insights into roles in diseases, including cancer and neurodegenerative disorders, making PTPζ (122.2) monoclonal antibody an invaluable tool for researchers studying these critical biological processes.

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PTPζ Antibody (122.2) References:

1. A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta.  |  Maeda, N., et al. 1999. J Biol Chem. 274: 12474-9. PMID: 10212223
2. A receptor-type protein tyrosine phosphatase PTP zeta is expressed in human cutaneous melanomas.  |  Goldmann, T., et al. 2000. Folia Histochem Cytobiol. 38: 19-20. PMID: 10763119
3. Receptor-like protein tyrosine phosphatase gamma (RPTPgamma), but not PTPzeta/RPTPbeta, inhibits nerve-growth-factor-induced neurite outgrowth in PC12D cells.  |  Shintani, T., et al. 2001. Dev Neurosci. 23: 55-69. PMID: 11173927
4. A chondroitin sulfate proteoglycan PTPzeta /RPTPbeta regulates the morphogenesis of Purkinje cell dendrites in the developing cerebellum.  |  Tanaka, M., et al. 2003. J Neurosci. 23: 2804-14. PMID: 12684467
5. A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases.  |  Krueger, NX. and Saito, H. 1992. Proc Natl Acad Sci U S A. 89: 7417-21. PMID: 1323835
6. Complex-type asparagine-linked oligosaccharides on phosphacan and protein-tyrosine phosphatase-zeta/beta mediate their binding to neural cell adhesion molecules and tenascin.  |  Milev, P., et al. 1995. J Biol Chem. 270: 24650-3. PMID: 7559574
7. Protein-tyrosine phosphatase epsilon. An isoform specifically expressed in mouse mammary tumors initiated by v-Ha-ras OR neu.  |  Elson, A. and Leder, P. 1995. J Biol Chem. 270: 26116-22. PMID: 7592814
8. Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo.  |  Brady-Kalnay, SM., et al. 1995. J Cell Biol. 130: 977-86. PMID: 7642713
9. Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects.  |  Ahmad, F., et al. 1995. J Clin Invest. 95: 2806-12. PMID: 7769120
10. Homophilic interactions mediated by receptor tyrosine phosphatases mu and kappa. A critical role for the novel extracellular MAM domain.  |  Zondag, GC., et al. 1995. J Biol Chem. 270: 14247-50. PMID: 7782276
11. Stimulation of receptor protein-tyrosine phosphatase alpha activity and phosphorylation by phorbol ester.  |  den Hertog, J., et al. 1995. Cell Growth Differ. 6: 303-7. PMID: 7794797
12. Neurons as well as astrocytes express proteoglycan-type protein tyrosine phosphatase zeta/RPTPbeta: analysis of mice in which the PTPzeta/RPTPbeta gene was replaced with the LacZ gene.  |  Shintani, T., et al. 1998. Neurosci Lett. 247: 135-8. PMID: 9655611

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PTPζ Antibody (122.2) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-PTPζ Antibody (122.2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PTPζ Antibody (122.2) Specifications

Alternate Product Name: PTPRZ1

Product Clone Name: 122.2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: PTPζ

Epitope Species: rat

Product Reactivity/Detection: PTPζ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for PTPζ Antibody (122.2): N/A