Date published: 2025-9-8

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Profilin-1 抗体 (H-4): sc-137236

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说明书
  • Profilin-1抗体(H-4)是小鼠单克隆IgM κ, 在6篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Profilin-1的N-terminus的氨基酸2-37之间
  • 推荐用于 mouse, rat 和 human 来源的Profilin-1 WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: 和 equine, bovine and porcine
  • m-IgGκ BP-HRP是Profilin-1 Antibody (H-4) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与Profilin-1 Antibody (H-4) 搭配使用(请参阅下面的订购信息)。有关其它 m-IgGκ BP 结合物,请参阅我们完整的小鼠 IgG 结合蛋白列表。

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関連項目

通过与肌动蛋白单体结合并隔离,蛋白丝调节肌动蛋白聚合。蛋白丝充当核苷酸交换因子,通过1:1的化学计量关系与肌动蛋白单体结合后,向肌动蛋白充能ATP。人类蛋白丝-1和蛋白丝-2分别由染色体17p13.2和3q25.1上的两个独立基因编码。蛋白丝-1和蛋白丝-2在肾脏中大量表达。蛋白丝-1在肺、肝、胎盘和肾脏中高度表达,而蛋白丝-2在脑和骨骼肌中高度表达。在小鼠脑的轴突和树突过程中,蛋白丝与动力蛋白I和突触素共定位。蛋白丝可能在介导细胞粘附中发挥作用。内皮细胞中蛋白丝的过表达导致对纤维连接蛋白的粘附增加。在食物过敏中,植物蛋白丝被认为是一种泛过敏原。案例研究表明,对芹菜、胡萝卜、西葫芦和花生等食物过敏的人实际上对这些食物中的蛋白丝蛋白质敏感。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Profilin-1 抗体 (H-4) 参考文献:

  1. Profilin-1 促进高血压引起的动脉重塑的发展。  |  Wang, Y., et al. 2014. J Histochem Cytochem. 62: 298-310. PMID: 24399041
  2. Profilin-1 对高级糖化终产物诱导的大鼠心脏损伤有促进作用。  |  Yang, D., et al. 2017. Mol Med Rep. 16: 6634-6641. PMID: 28901418
  3. Profilin 1 蛋白及其对癌症的影响  |  Wang, Y., et al. 2021. Oncology (Williston Park). 35: 402-409. PMID: 34264570
  4. Profilin-1 通过血管重塑和炎症参与了由高级糖化终产物诱发的大血管病变。  |  Xiao, ZL., et al. 2021. World J Diabetes. 12: 1875-1893. PMID: 34888013
  5. 暴露于二氧化钛纳米颗粒的肺微血管内皮细胞中 Cofilin-1 和 profilin-1 的表达。  |  An, MH., et al. 2022. Adv Clin Exp Med. 31: 1255-1264. PMID: 36000878
  6. 血管内皮异型蛋白-1 推动肾癌原发肿瘤微环境和肿瘤进展。  |  Gau, D., et al. 2023. J Biol Chem. 299: 105044. PMID: 37451478
  7. 长期消耗 profilin 1 或 F-肌动蛋白会导致微管的适应性反应。  |  Cisterna, BA., et al. 2024. J Cell Biol. 223: PMID: 38722279
  8. 30 名接受奴西那生治疗的脊髓性肌萎缩症 3 型患者的神经丝蛋白轻链和 profilin-1 动态变化。  |  Musso, G., et al. 2024. Eur J Neurol. 31: e16393. PMID: 38924263
  9. 肌动蛋白结合蛋白 profilin 1 定位于线粒体内,对线粒体的功能至关重要。  |  Read, TA., et al. 2024. EMBO Rep. 25: 3240-3262. PMID: 39026010
  10. 血管平滑肌细胞中 Profilin-1 的 m6A 修饰通过激活 p-ANXA2/STAT3 通路驱动表型转换和新内膜增生。  |  Gao, XF., et al. 2024. Arterioscler Thromb Vasc Biol. 44: 2543-2559. PMID: 39508106

订购信息

产品名称产品编号规格价格数量收藏夹

Profilin-1 抗体 (H-4)

sc-137236
200 µg/ml
$316.00

Profilin-1 (H-4): m-IgGκ BP-HRP 套装

sc-551979
200 µg Ab; 40 µg BP
$354.00

Profilin-1 (H-4) 中和勝肽

sc-137236 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-137236 P appropriate for?

Asked by: Trav11
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-03-01
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Rated 3 out of 5 by from GREAT PFN1 antibody for western only not IF IHCI am working with CNS and so far this antibody not working at all making me crazy. not good on either formalin fixed or frozen cns sections. I tried other mouse monoclonal clones also with no success.It has very very beautiful signal on westernblot though especially when you use binding RI 680 secondary from same company
Date published: 2020-08-07
Rated 5 out of 5 by from Excellent antibody for both IHC and WBLoved this antibody from the first time I used it - almost no optimizing required! Bought it in 2010 and it is only now (2017) that I am having to replace.
Date published: 2017-08-15
Rated 5 out of 5 by from Great immunofluorescence cytoplasmic stainingGreat immunofluorescence cytoplasmic staining in methanol-fixed NIH/3T3 cells. -SCBT QC
Date published: 2015-01-08
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Profilin-1 抗体 (H-4) is rated 4.5 out of 5 by 4.
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