Date published: 2025-9-7

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Profilin-1 抗体 (B-10): sc-137235

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说明书
  • Profilin-1 抗体 B-10 是小鼠单克隆 IgG1 κ,Profilin-1抗体, 在5篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Profilin-1的N-terminus的氨基酸2-37之间
  • Profilin-1 抗体 (B-10) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 Profilin-1; 也和以下物种反应,包括: 和 equine, bovine and porcine
  • 抗Profilin-1抗体(B-10)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Profilin-1 (B-10): sc-137235免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是Profilin-1 Antibody (B-10) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Profilin-1 Antibody (B-10) 打包提供(请参阅下面的订购信息)。

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関連項目

Profilin-1抗体(B-10)是一种IgG1κ小鼠单克隆Profilin-1抗体(也称为Profilin I抗体或PFN1抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人源的Profilin-1蛋白。Profilin-1抗体(B-10)可作为非偶联抗Profilin-1抗体形式,以及多种偶联形式的抗Profilin-1抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Profilins通过结合并隔离肌动蛋白单体来调节肌动蛋白聚合。Profilins作为核苷酸交换因子,通过1:1化学计量关系与肌动蛋白单体结合后,向肌动蛋白充能ATP。人Profilin-1和Profilin-2分别由位于染色体17p13.2和3q25.1的两个独立基因编码。Profilin-1和Profilin-2在肾脏中大量表达。Profilin-1在肺、肝、胎盘和肾脏中高度表达,而Profilin-2在脑和骨骼肌中高度表达。在小鼠脑的轴突和树突过程中,Profilins与动力蛋白I和突触蛋白共定位。Profilin可能在介导细胞粘附中发挥作用。内皮细胞中Profilin的过表达导致对纤维连接蛋白的粘附增加。在食物过敏中,植物Profilin被认为是一种泛过敏原。案例研究表明,对芹菜、胡萝卜、西葫芦和花生等食物过敏的人实际上对这些食物中的Profilin蛋白质敏感。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Profilin-1 抗体 (B-10) 参考文献:

  1. 胸腺肽 beta 4 和 profilin 对肌动蛋白核苷酸交换的控制。细胞中肌动蛋白聚合反应的潜在调控机制。  |  Goldschmidt-Clermont, PJ., et al. 1992. Mol Biol Cell. 3: 1015-24. PMID: 1330091
  2. Profilins 构成了功能性植物泛过敏原的一个新家族。  |  Valenta, R., et al. 1992. J Exp Med. 175: 377-85. PMID: 1370681
  3. 鉴定功能性 profilin 基因,确定其在染色体 17p13.3 子带的位置,并在一些米勒-迪克综合征患者中证实其缺失。  |  Kwiatkowski, DJ., et al. 1990. Am J Hum Genet. 46: 559-67. PMID: 1968707
  4. RhoA/mDia-1/profilin-1信号针对糖尿病视网膜病变中的微血管内皮功能障碍。  |  Lu, Q., et al. 2015. Graefes Arch Clin Exp Ophthalmol. 253: 669-80. PMID: 25791356
  5. profilin-1 在心血管疾病中的作用。  |  Allen, A., et al. 2021. J Cell Sci. 134: PMID: 33961053
  6. profilin-1 对不对称二甲基精氨酸诱导的血管病变相关性高血压的影响。  |  Ni, GH., et al. 2022. Kaohsiung J Med Sci. 38: 149-156. PMID: 34741409
  7. Profilin 1 缺乏会导致有丝分裂缺陷并降低基因组稳定性。  |  Scotto di Carlo, F., et al. 2023. Commun Biol. 6: 9. PMID: 36599901
  8. profilin-1 在高级糖化终产物(AGEs)诱导的血管病变中的作用。  |  Xie, Q., et al. 2023. J Diabetes Complications. 37: 108415. PMID: 36989867
  9. 克隆和表达一种新型人类 profilin 变异体 profilin II。  |  Honoré, B., et al. 1993. FEBS Lett. 330: 151-5. PMID: 8365484
  10. 1995 年第六届人类 3 号染色体制图国际研讨会报告。  |  Naylor, SL., et al. 1996. Cytogenet Cell Genet. 72: 255-70. PMID: 8641130
  11. profilin 对内皮细胞粘附性的调节。  |  Moldovan, NI., et al. 1997. Curr Biol. 7: 24-30. PMID: 9024619
  12. 在小鼠大脑中,profilin I 和 profilin II 与内细胞通路和肌动蛋白组装的调节因子缔合作用。  |  Witke, W., et al. 1998. EMBO J. 17: 967-76. PMID: 9463375

订购信息

产品名称产品编号规格价格数量收藏夹

Profilin-1 抗体 (B-10)

sc-137235
200 µg/ml
$316.00

Profilin-1 (B-10): m-IgG Fc BP-HRP 套装

sc-528880
200 µg Ab; 10 µg BP
$354.00

Profilin-1 (B-10): m-IgGκ BP-HRP 套装

sc-521463
200 µg Ab, 40 µg BP
$354.00

Profilin-1 (B-10): m-IgG1 BP-HRP 套装

sc-543188
200 µg Ab; 20 µg BP
$354.00

Profilin-1 抗体 (B-10) AC

sc-137235 AC
500 µg/ml, 25% agarose
$416.00

Profilin-1 抗体 (B-10) HRP

sc-137235 HRP
200 µg/ml
$316.00

Profilin-1 抗体 (B-10) FITC

sc-137235 FITC
200 µg/ml
$330.00

Profilin-1 抗体 (B-10) PE

sc-137235 PE
200 µg/ml
$343.00

Profilin-1 抗体 (B-10) Alexa Fluor® 488

sc-137235 AF488
200 µg/ml
$357.00

Profilin-1 抗体 (B-10) Alexa Fluor® 546

sc-137235 AF546
200 µg/ml
$357.00

Profilin-1 抗体 (B-10) Alexa Fluor® 594

sc-137235 AF594
200 µg/ml
$357.00

Profilin-1 抗体 (B-10) Alexa Fluor® 647

sc-137235 AF647
200 µg/ml
$357.00

Profilin-1 抗体 (B-10) Alexa Fluor® 680

sc-137235 AF680
200 µg/ml
$357.00

Profilin-1 抗体 (B-10) Alexa Fluor® 790

sc-137235 AF790
200 µg/ml
$357.00

Profilin-1 (B-10) 中和勝肽

sc-137235 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-137235 P appropriate for?

Asked by: Professor Griffin
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by from Good antibody to ucontrol of cytoplasmic extractsGood antibody to use as a control of for cytoplasmic extracts
Date published: 2018-10-22
Rated 5 out of 5 by from Very good Ab for WBI got a chance to test the Ab in WB. It showed unique band around 15 kDa. Samples from N2a cell lines, dilution was 1:500.
Date published: 2017-09-09
Rated 5 out of 5 by from A good antibodyThis antibody is used for IP detection, when diluted 1:800 is a good signal.
Date published: 2017-04-29
Rated 5 out of 5 by from Stains very brightly in cellsIn the experiment, Profilin-1 antibody stains very brightly in cells. Good antibody with clear signal.
Date published: 2017-02-05
Rated 5 out of 5 by from Great features!Great features! Distinct band is detected using this product! Nice quality! Got satisfactory results!
Date published: 2016-11-08
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Profilin-1 抗体 (B-10) is rated 5.0 out of 5 by 6.
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