p-KV4.2 Antibody (C-6): sc-377574

p-KV4.2 Antibody (C-6) is a mouse monoclonal IgM antibody that detects Thr 602 phosphorylated KV4.2 of human, mouse, rat, equine, canine, bovine, and ovine origin, as well as Thr 603 phosphorylated KV4.2 of avian origin, by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p-KV4.2 (C-6) antibody is available in a non-conjugated form, providing flexibility for various experimental needs. KV4.2 plays a crucial role in regulating neuronal excitability and cardiac action potentials as a key component of voltage-gated potassium channels that facilitate action potential repolarization in excitable cells. These channels maintain proper electrical activity of neurons and muscle cells, and dysfunction can lead to severe neurological and cardiac disorders. KV4.2 primarily localizes to neuronal plasma membranes, forming tetrameric structures with other KV subunits for precise ion flow control. This localization enables rapid and efficient electrical signal transmission, highlighting KV4.2′s importance in both central and peripheral nervous system function. Phosphorylation of KV4.2 at specific residues, such as Thr 602 by mitogen-activated protein kinase ERK2, modulates activity and influences channel dynamics, demonstrating intricate regulatory mechanisms in neuronal signaling.

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p-KV4.2 Antibody (C-6) References:

1. Kv4.2 phosphorylation by cyclic AMP-dependent protein kinase.  |  Anderson, AE., et al. 2000. J Biol Chem. 275: 5337-46. PMID: 10681507
2. Input-specific immunolocalization of differentially phosphorylated Kv4.2 in the mouse brain.  |  Varga, AW., et al. 2000. Learn Mem. 7: 321-32. PMID: 11040264
3. The A-type potassium channel Kv4.2 is a substrate for the mitogen-activated protein kinase ERK.  |  Adams, JP., et al. 2000. J Neurochem. 75: 2277-87. PMID: 11080179
4. Altered phosphorylation and localization of the A-type channel, Kv4.2 in status epilepticus.  |  Lugo, JN., et al. 2008. J Neurochem. 106: 1929-40. PMID: 18513371
5. Kv4.2 is a locus for PKC and ERK/MAPK cross-talk.  |  Schrader, LA., et al. 2009. Biochem J. 417: 705-15. PMID: 18795890
6. AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking.  |  Lin, L., et al. 2011. J Neurosci. 31: 1323-32. PMID: 21273417
7. Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes.  |  Liu, J., et al. 2015. PLoS One. 10: e0133274. PMID: 26196737
8. FMRP Mediates Chronic Ethanol-Induced Changes in NMDA, Kv4.2, and KChIP3 Expression in the Hippocampus.  |  Spencer, KB., et al. 2016. Alcohol Clin Exp Res. 40: 1251-61. PMID: 27147118
9. Modulation of Kv4.2/KChIP3 interaction by the ceroid lipofuscinosis neuronal 3 protein CLN3.  |  Seifert, C., et al. 2020. J Biol Chem. 295: 12099-12110. PMID: 32641494
10. Kv4.2 phosphorylation by PKA drives Kv4.2-KChIP2 dissociation, leading to Kv4.2 out of lipid rafts and internalization.  |  Li, Y., et al. 2022. Am J Physiol Cell Physiol. 323: C190-C201. PMID: 35508186

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-KV4.2 Antibody (C-6) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-p-KV4.2 Antibody (C-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-KV4.2 Antibody (C-6) Specifications

Alternate Product Name: KV4.2

Product Clone Name: C-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: Thr 602

Epitope Target: KV4.2

Epitope Species: human

Product Reactivity/Detection: Thr 602 phosphorylated KV4.2 of human, mouse, rat, equine, canine, bovine, and ovine origin and Thr 603 phosphorylated KV4.2 of avian origin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for p-KV4.2 Antibody (C-6): P: Blocking Peptide

The preferred p-KV4.2 antibody is p-KV4.2 Antibody (A-5): sc-377545.