OSBP2 Antibody (B-1): sc-365922
- OSBP2 Antibody (B-1) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-190 mapping at the N-terminus of OSBP2 of human origin
- OSBP2 Antibody (B-1) is recommended for detection of OSBP2 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-OSBP2 Antibody (B-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for OSBP2 Antibody (B-1) for WB and IHC(P) applications. These reagents are now offered in bundles with OSBP2 Antibody (B-1) (see ordering information below).
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OSBP2 Antibody (B-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects OSBP2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). OSBP2 (B-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Oxysterol-binding protein (OSBP) family, which includes OSBP1 and OSBP2, plays a crucial role in lipid metabolism and signal transduction, as well as vesicle transport. OSBP2 (B-1) monoclonal antibody recognizes a protein that is primarily localized in the testis, retina, and fetal liver, highlighting OSBP2′s significance in reproductive and developmental processes. Notably, OSBP2 interacts with 25-hydroxy-cholesterol (25-HC), a key regulator that suppresses the transcription of genes involved in cholesterol synthesis, such as HMG-CoA reductase and the low-density lipoprotein receptor (LDLR). By binding to 25-HC, OSBP2 modulates the extracellular signal-regulated kinase (ERK) signaling pathway, thereby influencing various cellular responses. OSBP2′s ability to translocate to the periphery of Golgi membranes upon oxysterol binding further underscores OSBP2′s dynamic role in cellular lipid transport and signaling.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
OSBP2 Antibody (B-1) References:
- Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina. | Moreira, EF., et al. 2001. J Biol Chem. 276: 18570-8. PMID: 11278871
- A family of 12 human genes containing oxysterol-binding domains. | Jaworski, CJ., et al. 2001. Genomics. 78: 185-96. PMID: 11735225
- Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments. | Wang, C., et al. 2002. Biochem J. 361: 461-72. PMID: 11802775
- The OSBP-related proteins: a novel protein family involved in vesicle transport, cellular lipid metabolism, and cell signalling. | Lehto, M. and Olkkonen, VM. 2003. Biochim Biophys Acta. 1631: 1-11. PMID: 12573443
- HLM/OSBP2 is expressed in chronic myeloid leukemia. | Henriques Silva, N., et al. 2003. Int J Mol Med. 12: 663-6. PMID: 12964051
- Characterization of the sterol-binding domain of oxysterol-binding protein (OSBP)-related protein 4 reveals a novel role in vimentin organization. | Wyles, JP., et al. 2007. Exp Cell Res. 313: 1426-37. PMID: 17350617
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OSBP2 Antibody (B-1) | sc-365922 | 200 µg/ml | $322.00 | |||
OSBP2 Antibody (B-1): m-IgGκ BP-HRP Bundle | sc-522423 | 200 µg Ab, 40 µg BP | $361.00 | |||
OSBP2 Antibody (B-1): m-IgG2a BP-HRP Bundle | sc-546117 | 200 µg Ab; 10 µg BP | $361.00 | |||
OSBP2 Antibody (B-1) AC | sc-365922 AC | 500 µg/ml, 25% agarose | $424.00 | |||
OSBP2 Antibody (B-1) HRP | sc-365922 HRP | 200 µg/ml | $322.00 | |||
OSBP2 Antibody (B-1) FITC | sc-365922 FITC | 200 µg/ml | $336.00 | |||
OSBP2 Antibody (B-1) PE | sc-365922 PE | 200 µg/ml | $349.00 | |||
OSBP2 Antibody (B-1) Alexa Fluor® 488 | sc-365922 AF488 | 200 µg/ml | $364.00 | |||
OSBP2 Antibody (B-1) Alexa Fluor® 546 | sc-365922 AF546 | 200 µg/ml | $364.00 | |||
OSBP2 Antibody (B-1) Alexa Fluor® 594 | sc-365922 AF594 | 200 µg/ml | $364.00 | |||
OSBP2 Antibody (B-1) Alexa Fluor® 647 | sc-365922 AF647 | 200 µg/ml | $364.00 | |||
OSBP2 Antibody (B-1) Alexa Fluor® 680 | sc-365922 AF680 | 200 µg/ml | $364.00 | |||
OSBP2 Antibody (B-1) Alexa Fluor® 790 | sc-365922 AF790 | 200 µg/ml | $364.00 |